A novel benzoyl-type fluorous protecting group for use in fluorous synthesis
A novel benzoyl-type fluorous protecting group for use in fluorous synthesis
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DOI：
10.1016/j.tetasy.2004.11.050
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发表时间：
2005-01-10
影响因子：
--
通讯作者：
Inazu, T
中科院分区：
文献类型：
--
作者：
Miura, T;Satoh, A;Inazu, T
TfBz-OH，一种新型的苯甲酰型氟保护剂。很容易准备。发现TfBz（三氟链型苯甲酰基）基团可以成功地引入到羟基官能团上，以高产率除去，并在脱保护后回收。TfBz基团的使用使得可以通过最低限度的柱色谱纯化来合成寡糖，因为每个合成中间体都易于通过氟-有机溶剂萃取来简单地纯化。(C)2004爱思唯尔有限公司保留所有权利。
TfBz-OH, a novel benzoyl-type fluorous protecting reagent. has been easily prepared. It was found that the TfBz (trisfluorous chain-type benzoyl) group call be successfully introduced onto a hydroxyl function, removed in high yield, and recycled after deprotection. The use of the TfBz group makes it possible to synthesize an oligosaccharide by minimal column chromatography purification, because each synthetic intermediate is easily purified simply by fluorous-organic solvent extraction. (C) 2004 Elsevier Ltd. All rights reserved.