A generalized Luria-Delbruck model
A generalized Luria-Delbruck model
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DOI：
10.1016/j.mbs.2005.07.003
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发表时间：
2005-10-01
影响因子：
4.3
通讯作者：
Moolgavkar, SH
中科院分区：
文献类型：
--
作者：
Dewanji, A;Luebeck, EG;Moolgavkar, SH
我们开发了Luria-Delbruck模型的扩展，该模型明确考虑了正常细胞的非指数生长和突变体的平均指数或Gompertz生长的出生-死亡过程。突变细胞的死亡在癌症进展过程中产生的克隆中可能是重要的。与之前在Luria-Delbruck模型上的工作中使用的纯出生过程相反，对突变细胞生长使用出生-死亡过程导致突变细胞群大小的额外泊松变异的大量增加，这需要在统计分析中加以解决。我们还讨论了与先前关于致癌模型的工作的联系。(c) 2005爱思唯尔公司版权所有。
We develop extensions of the Luria-Delbruck model that explicitly consider non-exponential growth of normal cells and a birth-death process with mean exponential or Gompertz growth of mutants. Death of mutant cells can be important in clones arising during cancer progression. The use of a birth-death process for growth of mutant cells, as opposed to a pure birth process as in previous work on the Luria-Delbruck model, leads to a large increase in the extra Poisson variation in the size of the mutant cell populations, which needs to be addressed in statistical analyses. We also discuss connections with previous work on carcinogenesis models. (c) 2005 Elsevier Inc. All rights reserved.