Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.
Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.
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DOI：
10.1038/nmat4624
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发表时间：
2016-07
期刊：
影响因子：
41.2
通讯作者：
Rogers JA
中科院分区：
文献类型：
--
作者：
Yu KJ;Kuzum D;Hwang SW;Kim BH;Juul H;Kim NH;Won SM;Chiang K;Trumpis M;Richardson AG;Cheng H;Fang H;Thomson M;Bink H;Talos D;Seo KJ;Lee HN;Kang SK;Kim JH;Lee JY;Huang Y;Jensen FE;Dichter MA;Lucas TH;Viventi J;Litt B;Rogers JA
生物可吸收硅电子技术为部署先进的植入式监测系统提供了前所未有的机会，这些系统可以消除与手术摘除相关的风险、成本和不适感。应用包括经皮或微创放置血管、心脏、整形外科、神经或其他装置后的术后监测和瞬时生理记录。我们提出了这些材料在被动和主动寻址的具有多路复用能力的生物可吸收硅电极阵列中的实施例，该阵列记录了来自皮质表面和星系下空间的在体电生理信号。该设备在急性和慢性记录中都能检测到正常的生理和癫痫样活动。对比研究表明，传感器的性能可与标准临床系统相媲美，并且与传统的临床皮层脑电(ECoG)电极相比，组织反应性降低。这项技术在神经接口中提供了广泛的适用性，在需要瞬时监测和调节生理功能、植入物完整性以及组织恢复或再生的疾病治疗中具有额外的潜在用途。
Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include post-operative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, that record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.