DIF, A DORSAL-RELATED GENE THAT MEDIATES AN IMMUNE-RESPONSE IN DROSOPHILA
DIF, A DORSAL-RELATED GENE THAT MEDIATES AN IMMUNE-RESPONSE IN DROSOPHILA
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DOI：
10.1016/0092-8674(93)90495-c
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发表时间：
1993-11-19
期刊：
影响因子：
64.5
通讯作者：
LEVINE, M
中科院分区：
文献类型：
--
作者：
IP, YT;REACH, M;LEVINE, M
果蝇胚胎的背腹侧（DV）轴的基因表达调控与哺乳动物免疫系统中的淋巴细胞限制性表达有着惊人的相似之处。两者都依赖于包含在核转运水平上受控制的rel结构域（背侧和NF-kappaB）的调节因子。果蝇中一种新的含有rel的基因Dif（背侧相关免疫因子）提供了这些看似不同的过程之间的潜在联系。虽然Dif位于果蝇的背侧，但它似乎不参与DV模式，而是在果蝇幼虫中介导免疫反应。Dif通常位于幼虫脂肪体的细胞质中，但在细菌感染或损伤时迅速积聚在细胞核中。有证据表明，一旦进入细胞核，Dif与免疫基因启动子区域中存在的kappab样序列基序结合。这些结果表明，哺乳动物和昆虫的免疫具有共同的进化起源。
There are striking parallels between the regulation of gene expression along the dorsoventral (DV) axis of Drosophila embryos and lymphoid-restricted expression in the mammalian immune system. Both depend on regulatory factors containing rel domains (dorsal and NF-kappaB) that are controlled at the level of nuclear transport. A novel Rel-containing gene in Drosophila, Dif (dorsal-related immunity factor), provides a potential link between these seemingly disparate processes. Although Dif maps close to dorsal, it does not appear to participate in DV patterning, but instead mediates an immune response in Drosophila larvae. Dif is normally localized in the cytoplasm of the larval fat body, but quickly accumulates in the nucleus upon bacterial infection or injury. Evidence is presented that once in the nucleus, Dif binds to kappaB-like sequence motifs present in promoter regions of immunity genes. These results suggest that mammalian and insect immunity share a common evolutionary origin.