RAPID ALTERATION OF THALAMOCORTICAL AXON MORPHOLOGY FOLLOWS PERIPHERAL DAMAGE IN THE NEONATAL RAT
RAPID ALTERATION OF THALAMOCORTICAL AXON MORPHOLOGY FOLLOWS PERIPHERAL DAMAGE IN THE NEONATAL RAT
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DOI：
10.1073/pnas.92.7.2549
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发表时间：
1995-03-28
影响因子：
11.1
通讯作者：
KILLACKEY, HP
中科院分区：
文献类型：
--
作者：
CATALANO, SM;ROBERTSON, RT;KILLACKEY, HP
在P3上观察出生日期（出生后0天；P0）眶下神经切面对大鼠体感觉皮层丘脑皮质轴突形态的影响。用碳青染料1,1'-二十八烷基-3,3,3',3'-四甲基多高氯酸碳青标记固定脑的丘脑纤维，重建单独的光转化丘脑皮质纤维。在P3的正常动物中，轴突第四层内的轴突末端已经开始形成，末端乔木的宽度与皮质“桶”相当。眶下神经切片后，丘脑皮质末端乔木的平均宽度明显大于同年龄正常大鼠的平均乔木宽度；然而，每个终端乔木的分支数量和总乔木长度在各组之间都没有差异。这些观察结果表明，外周在引导终端乔木形成中的作用是非常迅速的，并且在单个丘脑轴突的水平上发挥作用。此外，这些结果表明，大鼠体感觉皮层中单个轴突终端乔木形态与模式形成之间存在密切联系。
The effect of day of birth (postnatal day 0; P0) infraorbital nerve section on the morphology of individual thalamocortical axons in rat somatosensory cortex was examined on P3. Thalamic fibers were labeled in fixed brains with the carbocyanine dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate, and individual photoconverted thalamocortical fibers were reconstructed, In normal animals on P3, axon arbor terminal formation within layer IV has commenced and terminal arbor width is comparable to that of a cortical ''barrel.'' After infraorbital nerve section, the average width of thalamocortical terminal arbors is significantly greater than is the average arbor width of normal rats of the same age; however, neither the number of branches per terminal arbor nor total arbor length differs between groups, These observations suggest that the role of the periphery in guiding terminal arbor formation is exerted both very rapidly and at the level of the single thalamic axon, Further, these results indicate a close association between individual axon terminal arbor morphology and pattern formation in the rat somatosensory cortex.