Main causes of death in cirrhosis.
Main causes of death in cirrhosis.
复制标题
肝硬化死亡的主要原因。
DOI：
10.3109/00365528309182110
复制
发表时间：
1983
影响因子：
1.9
通讯作者：
N. Tygstrup
中科院分区：
文献类型：
--
作者：
P. Schlichting;E. Christensen;L. Fauerholdt;H. Poulsen;E. Juhl;N. Tygstrup
随访长达16年的532名肝硬化患者中，436例死亡的主要原因为肝衰竭（24%）、肝衰竭伴消化道出血（13%）、消化道出血（14%）、原发性肝细胞癌（4%）、其他肝脏相关原因（2%）、感染（7%）、心血管疾病（22%）、 肝外恶性肿瘤（9%）和其他非肝脏相关原因（5%）。总共有 57% 的人死于肝脏相关原因。诊断时观察时间短、生化活性高、肝脏结构明显改变、腹水和其他预后不良迹象的患者中，与肝脏相关的死亡发生率较高。研究结果支持这样的假设：肝硬化是一种具有初始活跃期和随后的非活跃期的疾病。一半患者接受泼尼松治疗，但这对感染或胃肠道出血等单一死亡原因的分布或频率没有明显影响。在生存方面对泼尼松治疗反应良好的患者组（无腹水的非酗酒女性）显示死亡原因与总材料中的死亡原因没有不同。
The main causes of 436 deaths among 532 patients with cirrhosis followed up for up to 16 years constituted liver failure (24%), liver failure with gastrointestinal bleeding (13%), gastrointestinal bleeding (14%), primary liver cell carcinoma (4%), other liver-related causes (2%), infections (7%), cardiovascular diseases (22%), extrahepatic malignancies (9%), and other non-liver-related causes (5%). Totally, 57% died of liver-related causes. A high frequency of liver-related death was found among patients with a short observation time, high biochemical activity, pronounced change in liver architecture, ascites, and other signs of a poor prognosis at the time of diagnosis. The findings favoured the hypothesis that cirrhosis of the liver is a disease with an initial active and a subsequent inactive phase. Half of the patients were treated with prednisone, but this had no detectable influence on the distribution of causes of or on the frequency of single causes of death as infections or gastrointestinal bleeding. The group of patients responding favourably to prednisone treatment with regard to survival (non-alcoholic women without ascites) showed causes of death not different from those of the total material.