MR evaluation of age-related increase of brain iron in young adult and older normal males
MR evaluation of age-related increase of brain iron in young adult and older normal males
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DOI：
10.1016/s0730-725x(96)00234-2
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发表时间：
1997-01-01
影响因子：
2.5
通讯作者：
Marder, SR
中科院分区：
文献类型：
--
作者：
Bartzokis, G;Beckson, M;Marder, SR
本研究的目的是将与年龄相关的脑铁增加的调查扩展到更年轻的年龄组，复制先前发表的结果，并进一步评估一种新的非侵入性磁共振（MR）方法用于测量组织铁（铁蛋白）水平的有效性。该方法包括测量组织横向弛豫率（R（2））对MR仪器场强的依赖性。在1.5和0.5 T下工作的两种MR仪器被用来测量额叶白色物质、尾状核、壳核和苍白球的场依赖性R（2）增加（FDRI）。对一组13名正常成年男性（年龄21-77岁）进行了检查，其中7名受试者年龄低于35岁，6名年龄高于35岁。正如从尸检和既往FDRI数据中所预期的那样，在尾状核、壳核和苍白球中观察到FDRI的稳健和显著的年龄相关性增加，苍白球FDRI在第二个十年急剧增加，并在30岁后达到平台。此外，我们复制了以前的报告，显示FDRI和公布的四个地区的脑铁水平之间的相关性非常高。这些数据复制并扩展了FDRI以前对大脑衰老的观察，并与死后脑铁与年龄相关的增加数据一致。这些结果与年龄相关的神经退行性疾病的调查，其中铁可能催化有毒的自由基反应。(C)1997年爱思唯尔科学公司
The purposes of this study were to extend the investigation of age-related increases in brain iron to a younger age group, replicate previously published results, and further evaluate the validity of a novel noninvasive magnetic resonance (MR) method for measuring tissue iron (ferritin) levels with specificity. The method consists of measuring the dependence of tissue transverse relaxation rates (R(2)) on the field strength of MR instruments. Two MR instruments operating at 1.5 and 0.5 T were used to measure the field-dependent R(2) increase (FDRI) in the frontal white matter, caudate, putamen, and globus pallidus. A group of 13 normal adult males(ages 21-77), with seven subjects below and six above age 35, was examined. As expected from postmortem and prior FDRI data, robust and significant age-related increases in FDRI were observed in the caudate, putamen, and globus pallidus, with the globus pallidus FDRI increasing sharply in the second decade and reaching a plateau after age 30. In addition, we replicated previous reports showing very high correlations between FDRI and published brain iron levels for the four regions examined. The data replicate and extend previous FDRI observations on brain aging and are consistent with postmortem data on age-related increases in brain iron. These results are relevant to the investigation of age-related neurodegenerative diseases in which iron may catalyze toxic free radical reactions. (C) 1997 Elsevier Science Inc.