Altered brain activity in severely obese women may recover after Roux-en Y gastric bypass surgery
Altered brain activity in severely obese women may recover after Roux-en Y gastric bypass surgery
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DOI：
10.1038/ijo.2013.60
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发表时间：
2014-03-01
影响因子：
4.9
通讯作者：
Schultes, B.
中科院分区：
文献类型：
--
作者：
Frank, S.;Wilms, B.;Schultes, B.
目的：神经影像学研究表明，肥胖（OB）受试者大脑活动的改变可能与他们的疾病有因果关系。Roux-en Y胃旁路手术（RYGB）会引起明显和持续的体重减轻，并可能影响大脑活动。本研究的目的是比较严重OB妇女（n = 11），正常体重妇女的大脑活动模式（NW，n = 11）和既往接受过RYGB手术的重度OB女性（RYGB，n = 9）平均3.4 +/- 0.8年（均> 1年）。设计：在一个包含食物和非食物相关图片的单回任务和静息状态下，通过功能性磁共振成像评估大脑活动。在实验过程中，饥饿感和饱腹感在视觉模拟量表上被反复评定。与NW和RYGB女性相比，OB女性表现出（1）在视觉刺激期间，小脑活动更高，梭状回活动更低，与图片类别无关;（2）在呈现低热量食物图片与高热量食物图片时，下丘脑活动更高，（3）在工作记忆任务中海马和小脑的活动更高;（4）在静息状态下默认模式网络的额叶区域的功能连接更强。NW和RYGB女性之间的大脑活动没有差异，无论是在图片呈现期间还是在静息状态下。RYGB妇女一般评价较低的饥饿和较高的饱腹感，而有OB和NW women.CONCLUSION：数据提供的证据，改变大脑活动模式严重OB妇女和建议，RYGB手术和/或手术引起的体重减轻扭转肥胖相关的改变，这些评级之间没有差异。
OBJECTIVE: Neuroimaging studies have demonstrated alterations in brain activity in obese (OB) subjects that might be causally linked to their disorder. Roux-en Y gastric bypass (RYGB) surgery induces a marked and sustained weight loss and may affect brain activity. The aim of this study was to compare brain activity pattern between severely OB women (n = 11), normal-weight women (NW, n = 11) and previously severely OB women who had undergone RYGB surgery (RYGB, n = 9) on average 3.4 +/- 0.8 years (all > 1 year) before the experiment.DESIGN: Brain activity was assessed by functional magnetic resonance imaging during a one-back task containing food- and non-food-related pictures and during resting state. Hunger and satiety were repeatedly rated on a visual analog scale during the experiment.RESULTS: As compared with NW and also with RYGB women, OB women showed (1) a higher cerebellar and a lower fusiform gyrus activity during the visual stimulation independently of the picture category, (2) a higher hypothalamic activation during the presentation of low-vs high-caloric food pictures, (3) a higher hippocampal and cerebellar activity during the working memory task and (4) a stronger functional connectivity in frontal regions of the default mode network during resting state. There were no differences in brain activity between the NW and RYGB women, both during picture presentation and during resting state. RYGB women generally rated lower on hunger and higher on satiety, whereas there were no differences in these ratings between the OB and NW women.CONCLUSION: Data provide evidence for an altered brain activity pattern in severely OB women and suggest that RYGB surgery and/or the surgically induced weight loss reverses the obesity-associated alterations.