Low free triiodothyronine is associated with contrast-induced acute kidney injury and long-term outcome in elderly patients who underwent percutaneous coronary intervention
Low free triiodothyronine is associated with contrast-induced acute kidney injury and long-term outcome in elderly patients who underwent percutaneous coronary intervention
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DOI：
10.14744/anatoljcardiol.2018.38228
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发表时间：
2019-02-01
影响因子：
1.3
通讯作者：
Zhu, Pengli
中科院分区：
文献类型：
--
作者：
Lin, Chunjin;Lin, Kaiyang;Zhu, Pengli
目的：游离三碘甲状腺原氨酸（fT(3)）低常见于老年心血管疾病患者。本研究的目的是评估老年患者经皮冠状动脉介入治疗（PCI）后，低fT(3)与造影剂诱导的急性肾损伤（CI-AKI）之间的关系，包括长期结局。方法：连续入选2012年1月至2015年12月行PCI的患者350例，年龄>= 75岁。PCI术前测量围术期甲状腺功能，包括fT(3)。低fT(3)被定义为fT(3) = 0.30 mg/dL或在造影剂暴露后48小时内SCr bb0相对于基线值增加50%。采用多因素logistic回归分析，分析低fT(3)是否是CI-AKI的独立危险因素。采用Cox回归分析评价低fT(3)与远期预后的关系。结果：46例（13.1%）患者发生CI-AKI。低fT(3)组CI-AKI发生率明显高于正常组(26.5% vs. 9.9%, p
Objective: Low free triiodothyronine (fT(3)) is common in elderly patients with cardiovascular disease. The purpose of this study was to evaluate the relationship between low fT(3) and contrast-induced acute kidney injury (CI-AKI), including the long-term outcomes, in elderly patients after a percutaneous coronary intervention (PCI).Methods: A total of 350 patients aged >= 75 years who underwent PCI between January 2012 and December 2015 were consecutively enrolled. The perioperative thyroid function, including fT(3), was measured before PCI. A low fT(3) was defined as fT(3) = 0.30 mg/dL or a relative increase in SCr >= 50% from the baseline value within 48 hours after contrast media exposure. A multivariate logistic regression analysis was applied to analyze whether low fT(3) was an independent risk factor for CI-AKI. The Cox regression analysis was used to evaluate the relationship between low fT(3) and long-term prognosis.Results: A total of 46 (13.1%) patients developed CI-AKI. The incidence of CI-AKI was significantly higher in the low fT(3) group than in the normal group (26.5% vs. 9.9%, p