Galactose, Glucose, and Lactate Concentrations in the Portal Venous and Arterial Circulations of Newborn Lambs after Nursing
Galactose, Glucose, and Lactate Concentrations in the Portal Venous and Arterial Circulations of Newborn Lambs after Nursing
复制标题
哺乳后新生羔羊门静脉和动脉循环中的半乳糖、葡萄糖和乳酸浓度
作者：
J. Kaempf;Hai;J. Groothuis;F. Battaglia;G. Zerbe;J. W. Sparks
摘要：我们使用长期留置导管的新生羔羊来研究无应激的餐后状态下的碳水化合物代谢。羔羊禁食 5 小时，然后允许其从母亲那里随意哺乳 20 分钟。然后从门静脉和动脉循环中连续测定全血半乳糖、葡萄糖和乳酸浓度。摄入牛奶后门静脉半乳糖浓度显着增加，但动脉半乳糖浓度相对基线没有增加，除非门静脉半乳糖浓度超过 10-12 mg/dl，表明肝脏半乳糖清除率存在阈值效应。两个循环中的葡萄糖浓度均显着增加，在所有情况下门静脉半乳糖浓度>动脉半乳糖浓度。半乳糖和葡萄糖以大致相等的速率从肠道吸收。摄入乳糖后，乳酸盐不会在很大程度上被门静脉循环吸收。
ABSTRACT: We have used the newborn lamb prepared with chronic indwelling catheters to study carbohydrate metabolism in the unstressed, postprandial state. Lambs were fasted 5 h and then allowed to nurse ad libitum from their mothers for 20 min. Serial determinations of whole blood galactose, glucose, and lactate concentration were then made from the portal venous and arterial circulations. Portal venous galactose concentration increased significantly after milk ingestion, but arterial galactose concentration did not increase from baseline unless the portal venous galactose concentration exceeded 10–12 mg/dl suggesting a threshold effect for hepatic galactose clearance. Glucose concentration increased significantly in both circulations with portal venous galactose concentration > arterial galactose concentration in all cases. Galactose and glucose were absorbed from the intestine at approximately equal rates. Lactate was not absorbed into the portal venous circulation to any great extent after lactose ingestion.