The Synthesis of Taurine from Sulfate II. Chick Liver Phosphoadenosinephosphosulfate-Transferase 1
The Synthesis of Taurine from Sulfate II. Chick Liver Phosphoadenosinephosphosulfate-Transferase 1
复制标题
从硫酸盐合成牛磺酸 II。
DOI：
10.3181/00379727-132-34278
复制
发表时间：
1969
影响因子：
--
通讯作者：
W. G. Martin
中科院分区：
文献类型：
--
作者：
R. J. Miraglia;W. G. Martin
摘要 证明了鸡肝脏中存在 PAPS 转移酶，并分离并部分纯化了该酶。证明了牛磺酸合成中需要 PAPS 作为该转移酶的底物。对受体分子和最终变成牛磺酸的碳部分的起源的研究表明，蛋氨酸可能直接参与该合成。研究表明，蛋氨酸的羧基和甲基碳都没有变成牛磺酸碳，而蛋氨酸剩余的一些碳则出现在牛磺酸分子中。
Summary The existence of PAPS-transferase in chick liver was demonstrated and this enzyme was isolated and partially purified. The requirement of PAPS as a substrate for this transferase in the synthesis of taurine was demonstrated. Studies on the origin of the acceptor molecule and the carbon moiety which ultimately becomes taurine indicated that methionine may be directly involved in this synthesis. Studies showed that neither the carboxyl nor the methyl carbon of methionine became taurine carbon, while some of the remaining carbons of methionine appeared in the taurine molecule.