Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the brain.
Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the brain.
复制标题
苯乙醇胺 N-甲基转移酶和多巴胺-β-羟化酶抑制对大脑中肾上腺素水平的影响。
DOI：
10.1016/0024-3205(77)90310-1
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发表时间：
1977
期刊：
影响因子：
6.1
通讯作者：
M. Goldstein
中科院分区：
文献类型：
--
作者：
A. Sauter;J. Y. Lew;Y. Baba;M. Goldstein
本文研究了苯乙醇胺N-甲基转移酶（PNMT）和多巴胺-β-羟化酶（DβH）抑制对脑内特定区域肾上腺素含量的影响。SKF 64139是一种强效PNMT抑制剂，可有效降低脑肾上腺素水平。SKF 64139抑制PNMT的时间过程与脑中肾上腺素水平的降低平行。二乙基二硫代氨基甲酸酯（DDC）是一种有效的DβH抑制剂，可有效降低大脑分析区域的去甲肾上腺素和肾上腺素水平，并升高多巴胺水平。大脑中的肾上腺素水平似乎受到与肾上腺相似的生物合成控制。
The effects of phenylethanolamine N-methyltransferase (PNMT) and dopamine-β-hydroxylase (DβH) inhibition on the epinephrine content in specific regions of the brain were studied. SKF 64139, a potent PNMT inhibitor, is effective in lowering brain epinephrine levels. The time course of PNMT inhibition by SKF 64139 parallels the lowering of epinephrine levels in the brain. Diethyldithiocarbamate (DDC), a potent inhibitor of DβH, is effective in lowering norepinephrine and epinephrine levels and in elevating dopamine levels in the analyzed regions of the brain. The epinephrine levels in the brain appear to be under similar biosynthetic control as in the adrenal glands.