An optofluidic channel model for in vivo nanosensor networks in human blood
An optofluidic channel model for in vivo nanosensor networks in human blood
复制标题
人体血液体内纳米传感器网络的光流控通道模型
DOI：
10.1117/12.2262824
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Jornet, Josep M.
中科院分区：
文献类型：
--
作者：
Hall, Russell D.;Blowers, Misty;Williams, Jonathan;Johari, Pedram;Jornet, Josep M.
体内无线纳米传感器网络（iWNSN）由具有前所未有的传感和驱动能力的纳米级通信设备组成，能够在人体内运行。 iWNSN 是一项颠覆性技术，能够在细胞和亚细胞水平上监测和控制生物过程。与对从人体提取的样本进行的离体测量相比，iWNSN 可以跟踪（子）细胞过程发生的时间和地点。纳米电子学、纳米光子学和无线通信领域的重大进展正在实现纳米传感器的互连。其中，具有亚微米足迹的等离子体纳米激光器、能够将光限制在纳米结构中的等离子体纳米天线以及具有无与伦比的灵敏度的单光子探测器，使得植入的纳米传感器之间能够在近红外和光传输窗口中进行通信。受这些结果的启发，本文开发了一种光流控通道模型来研究人体血液中一对体内纳米传感器之间的通信特性和时间动态。开发的模型建立在作者最近通过多层单细胞和细胞组件进行光传播建模的工作基础上，并考虑了人体循环系统中红细胞的几何、电磁和微流体特性。所提出的模型指导了纳米传感器之间实用通信策略的开发，并为新的纳米生物传感策略铺平了道路，该策略能够通过检测由血细胞形状变化或病原体存在引起的通道脉冲响应的微小变化来识别疾病。
In vivo Wireless Nanosensor Networks (iWNSNs) consist of nano-sized communicating devices with unprecedented sensing and actuation capabilities, which are able to operate inside the human body. iWNSNs are a disruptive technology that enables the monitoring and control of biological processes at the cellular and subcellular levels. Compared to ex vivo measurements, which are conducted on samples extracted from the human body, iWNSNs can track (sub) cellular processes when and where they occur. Major progress in the field of nanoelectronics, nanophotonics and wireless communication is enabling the interconnection of nanosensors. Among others, plasmonic nanolasers with sub-micrometric footprint, plasmonic nano-antennas able to confine light in nanometric structures, and single-photon detectors with unrivaled sensitivity, enable the communication among implanted nanosensors in the near infrared and optical transmission windows. Motivated by these results, in this paper, an optofluidic channel model is developed to investigate the communication properties and temporal dynamics between a pair of in vivo nanosensors in the human blood. The developed model builds upon the authors’ recent work on light propagation modeling through multi-layered single cells and cell assemblies and takes into account the geometric, electromagnetic and microfluidic properties of red blood cells in the human circulatory system. The proposed model guides the development of practical communication strategies among nanosensors, and paves the way through new nano-biosensing strategies able to identify diseases by detecting the slight changes in the channel impulse response, caused by either the change in shape of the blood cells or the presence of pathogens.
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DOI：
10.1177/0271678x15619428
发表时间：
2016-11
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Schmid F;Wachsmuth L;Schwalm M;Prouvot PH;Jubal ER;Fois C;Pramanik G;Zimmer C;Faber C;Stroh A
通讯作者：
Stroh A
正常人体血液在常温和低温条件下的粘度。
影响因子：
3.3
作者：
P. Rand;E. Lacombe;Hamilton E. Hunt;W. H. Austin
通讯作者：
W. H. Austin
人体解剖学和生理学
DOI：
--
发表时间：
2010
期刊：
影响因子：
--
作者：
Nakatani K;Sakabe M;Nakajima Y.;仲谷和記
通讯作者：
仲谷和記
影响因子：
3.9
作者：
Guo, Hongzhi;Johari, Pedram;Sun, Zhi
通讯作者：
Sun, Zhi
用于深部脑刺激的无线光遗传学神经尘埃
DOI：
10.1109/healthcom.2016.7749532
发表时间：
2016
期刊：
Applications and Services (Healthcom
影响因子：
--
作者：
Wirdatmadja, Stefanus A.;Balasubramaniam, Sasitharan;Koucheryavy, Yevgeni;Jornet, Josep Miquel
通讯作者：
Jornet, Josep Miquel