Is It Me or My Hormones? Neuroendocrine Activation Profiles to Visual Food Stimuli Across the Menstrual Cycle
Is It Me or My Hormones? Neuroendocrine Activation Profiles to Visual Food Stimuli Across the Menstrual Cycle
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DOI：
10.1210/jc.2016-3921
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发表时间：
2017-09-01
影响因子：
5.8
通讯作者：
Weiss, Ram
中科院分区：
文献类型：
--
作者：
Arnoni-Bauer, Yardena;Bick, Atira;Weiss, Ram
背景：动态平衡能量平衡是通过下丘脑控制的，而控制奖赏和认知决策的区域对享乐饮食至关重要。月经周期不同，进食不同，在黄体中期和黄体中期达到峰值。目的：测试在卵泡中期和黄体中期有规律周期的女性和单相口服避孕药(OCP)使用者对视觉食物提示的反应。设计：受试者在四个时间点接受视觉食物提示时进行功能磁共振成像：卵泡中期和黄体中期的禁食和进食条件。患者：20名有规律周期的女性和12名单相OCP，年龄18-35岁。主要观察指标：动态平衡(下丘脑)，奖赏(杏仁核，壳核和额叶)，额叶(前扣带皮质，额叶背外侧前皮质)，和视觉区域(距骨核和枕叶外侧皮质)。地点：三级医院。结果：在有规律周期的女性中，与动态平衡相关的脑区，也包括奖赏系统、执行额区和传入视觉区域，在黄体期的激活程度高于卵泡期。在视觉区域内，可以看到荷尔蒙和饮食状态的双重影响。在服用单相OCPs的女性中，发现了让人想起黄体期的活动，其特征是黄体酮浓度永久升高。雄激素、皮质醇、睾酮和胰岛素水平与奖赏和视觉区域激活显著相关。结论：激素机制影响女性大脑内稳、情绪和注意力区域对食物提示的反应。这些发现与整个周期中的饮食行为的关系需要进一步研究。
Context: Homeostatic energy balance is controlled via the hypothalamus, whereas regions controlling reward and cognitive decision-making are critical for hedonic eating. Eating varies across the menstrual cycle peaking at the midluteal phase.Objective: To test responses of females with regular cycles during midfollicular and midluteal phase and of users of monophasic oral contraception pills (OCPs) to visual food cues.Design: Participants performed a functional magnetic resonance imaging while exposed to visual food cues in four time points: fasting and fed conditions in midfollicular and midluteal phases.Patients: Twenty females with regular cycles and 12 on monophasic OCP, aged 18 to 35 years.Main Outcome Measures: Activity in homeostatic (hypothalamus), reward (amygdala, putamen and insula), frontal (anterior cingulate cortex, dorsolateral prefrontal cortex), and visual regions (calcarine and lateral occipital cortex). Setting: Tertiary hospital.Results: In females with regular cycles, brain regions associated with homeostasis but also the reward system, executive frontal areas, and afferent visual areas were activated to a greater degree during the luteal compared with the follicular phase. Within the visual areas, a dual effect of hormonal and prandial state was seen. In females on monophasic OCPs, characterized by a permanently elevated progesterone concentration, activity reminiscent of the luteal phase was found. Androgen, cortisol, testosterone, and insulin levels were significantly correlated with reward and visual region activation.Conclusions: Hormonal mechanisms affect the responses of women's homeostatic, emotional, and attentional brain regions to food cues. The relation of these findings to eating behavior throughout the cycle needs further investigation.