The prevalence and demographic determinants of blood donors receiving testosterone replacement therapy at a large USA blood service organization.
The prevalence and demographic determinants of blood donors receiving testosterone replacement therapy at a large USA blood service organization.
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DOI：
10.1111/trf.15754
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发表时间：
2020-05
期刊：
影响因子：
2.9
通讯作者：
Kanias T
中科院分区：
文献类型：
--
作者：
Hazegh K;Bravo MD;Kamel H;Dumont L;Kanias T
由于红细胞增多，接受睾酮替代疗法(TRT)的献血者通常需要治疗性静脉切割术。合格的TRT捐献者捐献的红细胞(RBC)被批准采集和输血。这项研究旨在确定美国一家大型血液服务组织中TRT献血者的患病率和人口统计学决定因素。TRT捐赠者和匹配对照的献血数据是从2017-2018年间16个血液中心的去身份电子捐赠者数据库中收集的。人口统计学决定因素包括种族、性别、年龄、血红蛋白(Hb)、体重指数(BMI)、平均动脉压(MAP)和两年内捐献的频率。TRT捐赠者占捐赠者总数的1.6%，2018年生产了2.2%的红细胞单位。TRT供者多为中年白人或西班牙裔男性，肥胖率高(50.8%的TRT供者体重指数≥为30 kg/m2，对照组为36.2%)，高强度捐献频率(2年内捐献1~29次，对照组为1~12次)。TRT供者的MAP和Hb显著高于对照组(MAP 99.9±9.81vs.96.5±10.1 mm Hg；Hb17.8±1.44vs.15.6±1.37g/dL)，差异有统计学意义(P<；0.0001)。捐献一年与TRT捐赠者的MAP和Hb显著下降有关。TRT与红细胞增多症和肥胖症的高患病率相关，这可能解释了密集捐献频率、高MAP和Hb的原因。频繁的静脉抽血对血压和Hb水平有适度的积极影响。TRT对RBC产品质量的潜在影响需要进一步评估。
Blood donors receiving testosterone replacement therapy (TRT) often require therapeutic phlebotomy due to erythrocytosis. Red blood cells (RBCs) donated by eligible TRT donors are approved for collection and transfusion. This study was aimed at defining the prevalence and demographic determinants of TRT donors at a large USA blood service organization. Donation data from TRT donors and matched controls was collected from a de-identified electronic donor database across 16 blood centers in 2017–2018. Demographic determinants included race, sex, age, hemoglobin (Hb), body mass index (BMI), mean arterial pressure (MAP), and the frequency of donations in the 2-year period. TRT donors comprised 1.6% of the donor population and produced 2.2% of RBC units during 2018. TRT donors were likely to be middle-aged white or Hispanic men, with high prevalence of obesity (50.8% of TRT donors had BMI ≥30 kg/m2 compared with 36.2% in controls) and intensive donation frequency (1 to 29 donations in 2 years vs. 1 to 12 in controls). TRT donors had significantly (p < 0.0001) higher MAP and Hb compared with controls (MAP 99.9 ± 9.81 vs. 96.5 ± 10.1 mmHg; Hb 17.8 ± 1.44 vs. 15.6 ± 1.37 g/dL). One year of donations was associated with significant decreases in MAP and Hb for TRT donors. TRT is associated with high prevalence of erythrocytosis and obesity that may explain the intensive donation frequency, high MAP, and Hb. Frequent phlebotomies had a moderately positive effect on blood pressure and Hb levels. Potential implications of TRT on the quality of the RBC products require further evaluation.
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影响因子：
2.8
作者：
Yabluchanskiy A;Tsitouras PD
通讯作者：
Tsitouras PD
影响因子：
2.9
作者：
Kanias, Tamir;Sinchar, Derek;Gladwin, Mark T.
通讯作者：
Gladwin, Mark T.
影响因子：
6.6
作者：
Rao, Pravin Kumar;Boulet, Sheree L.;Ross, Lawrence S.
通讯作者：
Ross, Lawrence S.
影响因子：
3.6
作者：
Jones, Steven D Jr;Dukovac, Thomas;Hellstrom, Wayne J G
通讯作者：
Hellstrom, Wayne J G
影响因子：
3.2
作者：
Murphy, Edward L.;Schlumpf, Karen;Busch, Michael P.
通讯作者：
Busch, Michael P.