Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia
Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia
复制标题
中国首发、未接受药物治疗的精神分裂症患者对声惊吓的前脉冲抑制受损
DOI：
10.3760/cma.j.issn.0366-6999.20122077
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发表时间：
2013-02-05
影响因子：
6.1
通讯作者：
Zhou Dong-feng
中科院分区：
文献类型：
--
作者：
Wang Zhi-ren;Tan Yun-long;Zhou Dong-feng
精神分裂症患者在信息处理方面有明显的异常，这种异常可以通过声惊反射的脉冲前抑制（PPI）来观察到，PPI缺陷被认为是精神分裂症的一个候选内表型标志。然而，关于中国精神分裂症患者的PPI和相关措施的信息很少。本研究旨在探讨中国精神分裂症患者可能存在的声惊反射缺陷。方法对31例中国首发药物治疗型精神分裂症患者和30例年龄、性别匹配的健康对照进行声刺激、习惯化和PPI惊吓反应检测。惊吓试验当日，采用阳性和阴性综合征量表（PANSS）评定患者的精神病理症状。结果与健康对照组相比，患者在间隔60 ms （PPI60, P < 0.05）时的惊吓反应和PPI缺陷显著降低，而在间隔30和120 ms时则无显著降低。精神分裂症患者PPI60与PANSS阳性量表得分有较强的相关性（P < 0.05）。结论我们的研究结果证实了中国精神分裂症患者PPI受损，提示感觉运动门控缺陷与精神分裂症患者临床症状之间可能存在关系。
Background Patients with schizophrenia have prominent abnormality in information processing that can be observed by measures of prepulse inhibition (PPI) of acoustic startle reflex and PPI deficits have been considered as a candidate endophenotypic marker of schizophrenia. However, there has been little information on PPI and related measures in Chinese patients with schizophrenia. The research was to explore the deficits of acoustic startle reflex that might exist in Chinese patients with schizophrenia.Methods Startle response to acoustic stimuli, habituation, and PPI were examined in 31 Chinese patients with first-episode, medication-naive schizophrenia and 30 age- and sex- matched healthy Chinese controls. At the same day of startle testing, psychopathological symptoms of the patients were assessed with the Positive and Negative Syndrome Scale (PANSS).Results Compared with healthy controls, patients exhibited the significant reduction in startle response and PPI deficits at 60 milliseconds (ms) intervals (PPI60, P < 0.05) but not at 30 or 120 ms intervals. Furthermore, there was a relatively strong correlation between PPI60 (P < 0.05) and scores of positive scale of PANSS in patients with schizophrenia.Conclusion Our findings confirmed impaired PPI in Chinese patients with schizophrenia and suggested that a relationship between sensorimotor gating deficits and clinical symptoms of patients with schizophrenia might exist.