Objective assessment of motor activity in a clinical sample of adults with attention-deficit/hyperactivity disorder and/or cyclothymic temperament.
Objective assessment of motor activity in a clinical sample of adults with attention-deficit/hyperactivity disorder and/or cyclothymic temperament.
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DOI：
10.1186/s12888-022-04242-1
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发表时间：
2022-09-14
期刊：
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
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大多数关于运动活动模式的研究都是在患有情绪障碍的成年人身上进行的，但很少有研究调查共病的注意力缺陷/多动障碍（ADHD）或可能影响临床病程和症状的气质因素。循环型气质（CT）与功能障碍特别相关。临床特征定义这两种疾病，但客观的，这些疾病的生物标志物可以提供重要的见解，关于病理生理学和分类。招募了76名需要ADHD、情绪或焦虑障碍诊断评估的患者。进行了全面的诊断评估，包括孟菲斯、比萨、巴黎和圣地亚哥气质评估的CT量表-自动问卷（TEMPS-A）、神经心理学测试和腕动计。ADHD的诊断依据DSM-IV标准。在这个临床样本中有一系列不同的条件，但在这里，我们报告了与运动活动有关的CT和ADHD的存在。招募了29名健康对照。我们使用线性和非线性数学方法分析了运动活动时间序列，特别关注活动记录中的活动期和非活动期。40名患者符合ADHD的标准，其余患者接受其他精神病诊断（临床对照）。42例患者符合CT标准。22名患者符合ADHD和CT的标准，18名患者符合ADHD的标准而没有CT，15名患者两者都没有。在总样本和ADHD子样本中，CT患者的活动期/非活动期的比率显著低于无CT患者。CT与客观评估的运动活动变化相关，这意味着这些患者的运动行为调节系统与健康对照和无CT的临床对照不同。研究结果表明，体动计可以补充CT和ADHD的临床评估，并可能提供一个客观的标记物CT。在线版本包含补充材料，可通过10.1186/s12888-022-04242-1获得。
Most research on patterns of motor activity has been conducted on adults with mood disorders, but few studies have investigated comorbid attention-deficit/hyperactivity disorder (ADHD) or temperamental factors that may influence the clinical course and symptoms. Cyclothymic temperament (CT) is particularly associated with functional impairment. Clinical features define both disorders, but objective, biological markers for these disorders could give important insights with regard to pathophysiology and classification. Seventy-six patients, requiring diagnostic evaluation of ADHD, mood or anxiety disorders were recruited. A comprehensive diagnostic evaluation, including the CT scale of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego – Auto-questionnaire (TEMPS-A), neuropsychological tests and actigraphy, was performed. ADHD was diagnosed according to the DSM-IV criteria. There was a range of different conditions in this clinical sample, but here we report on the presence of CT and ADHD in relation to motor activity. Twenty-nine healthy controls were recruited. We analyzed motor activity time series using linear and nonlinear mathematical methods, with a special focus on active and inactive periods in the actigraphic recordings. Forty patients fulfilled the criteria for ADHD, with the remainder receiving other psychiatric diagnoses (clinical controls). Forty-two patients fulfilled the criteria for CT. Twenty-two patients fulfilled the criteria for ADHD and CT, 18 patients met the criteria for ADHD without CT, and 15 patients had neither. The ratio duration of active/inactive periods was significantly lower in patients with CT than in patients without CT, in both the total sample, and in the ADHD subsample. CT is associated with objectively assessed changes in motor activity, implying that the systems regulating motor behavior in these patients are different from both healthy controls and clinical controls without CT. Findings suggest that actigraphy may supplement clinical assessments of CT and ADHD, and may provide an objective marker for CT. The online version contains supplementary material available at 10.1186/s12888-022-04242-1.
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影响因子：
8.6
作者：
Nakamura, Toru;Kiyono, Ken;Yamamoto, Yoshiharu
通讯作者：
Yamamoto, Yoshiharu
影响因子：
6.6
作者：
Akiskal, HS;Akiskal, K;Hantouche, EG
通讯作者：
Hantouche, EG
影响因子：
3
作者：
Halmoy, Anne;Fasmer, Ole Bernt;Haavik, Jan
通讯作者：
Haavik, Jan
影响因子：
3.7
作者：
Nakamura, Toru;Takumi, Toru;Yamamoto, Yoshiharu
通讯作者：
Yamamoto, Yoshiharu
DOI：
10.3390/s131012852
发表时间：
2013-09-25
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Khusainov R;Azzi D;Achumba IE;Bersch SD
通讯作者：
Bersch SD