LBH589 enhances T cell activation in vivo and accelerates graft-versus-host disease in mice.
LBH589 enhances T cell activation in vivo and accelerates graft-versus-host disease in mice.
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LBH589在体内增强了T细胞活化，并加速了小鼠的移植物抗宿主病。
DOI：
10.1016/j.bbmt.2012.06.002
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发表时间：
2012-08
影响因子：
4.3
通讯作者：
Yu, Xue-Zhong
中科院分区：
文献类型：
--
作者：
Wang, Dapeng;Iclozan, Cristina;Liu, Chen;Xia, Chongqing;Anasetti, Claudio;Yu, Xue-Zhong
Histone deacetylase inhibitors (HDACi) are a new class of compounds that induce acetylation of histone lysine tails in chromatin and modify gene expression. The FDA approved HDACi, Vorinostat or suberoylanilide hydroxamic acid (SAHA), has been shown to inhibit tumor cell growth and the production of pro-inflammatory cytokines. In preclinical allogeneic transplantation models, SAHA induces graft-versus-host disease (GVHD) amelioration in treated mice without impairing graft-versus-leukemia (GVL). LBH589 (Panobinostat), a structurally novel cinnamic hydroxamic acid class, is an HDACi more potent than SAHA. In the current work, we tested the hypothesis that LBH589 would be highly effective in the prevention of GVHD. Using mouse model of allogeneic bone marrow transplantation (BMT), we unexpectedly found that treatment with LBH589 accelerated GVHD, in contrast to the treatment with SAHA that alleviated GVHD. Accelerated GVHD in the recipients treated with LBH589 was associated with elevated Th1 cytokines in recipient serum, enhanced CXCR3 expression on donor T cells, and T-cell infiltration in the liver. The current study highlights the distinct effects of pan HDACi on allogeneic BMT, and alerts that LBH589 (Panobinostat) could have adverse effect on GVHD, and possibly on other inflammatory diseases.
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影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
组蛋白脱乙酰基酶2介导的糖皮质激素受体的脱乙酰基化可以抑制NF-kappab。
影响因子：
15.3
作者：
Ito, Kazuhiro;Yamamura, Satoshi;Essilfie-Quaye, Sarah;Cosio, Borja;Ito, Misako;Barnes, Peter J;Adcock, Ian M
通讯作者：
Adcock, Ian M
影响因子：
20.3
作者：
Yi, Tangsheng;Chen, Ying;Zeng, Defu
通讯作者：
Zeng, Defu
DOI：
10.4049/jimmunol.0903610
发表时间：
2010-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Grausenburger R;Bilic I;Boucheron N;Zupkovitz G;El-Housseiny L;Tschismarov R;Zhang Y;Rembold M;Gaisberger M;Hartl A;Epstein MM;Matthias P;Seiser C;Ellmeier W
通讯作者：
Ellmeier W
影响因子：
4.4
作者：
Glauben, Rainer;Batra, Arvind;Siegmund, Britta
通讯作者：
Siegmund, Britta