In vitro screening of leishmanicidal activity in Myanmar timber extracts
In vitro screening of leishmanicidal activity in Myanmar timber extracts
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DOI：
10.1248/bpb.27.921
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发表时间：
2004-06-01
影响因子：
2
通讯作者：
Sekita, S
中科院分区：
文献类型：
--
作者：
Takahashi, M;Fuchino, H;Sekita, S
检查了属于27个家庭的75种缅甸木材提取物的杀利什曼活性。部分木材提取物具有明显的杀利什曼原虫活性，其中以垂盆草提取物的活性最强（MLC 3.1 μ g/ml，MIC 1.6 μ g/ml）。显示出有效活性的其他木材提取物包括来自锯叶雪松、香椿、香心树、红厚壳、栽培黄檀、Grevillea robusta、腺叶单隔藻、含笑和柚木的那些。从文献检索的报告，这些植物的化学成分，大多数成分被发现是醌衍生物或其他化合物与不饱和羰基。
Seventy-five Myanmar timber extracts belonging to 27 families were examined for their leishmanicidal activities. Some timber extracts had significant leishmanicidal activity, especially extracts of Millettia pendula, which exhibited the most potent activity (MLC 3.1mug/ml, MIC 1.6mug/ml). Other timber extracts showing potent activity included those from Cedrela serrata, Cedrela toona, Cordia fragrantissima, Calophyllum kunstleri, Dalbergia cultrate, Grevillea robusta, Haplophragma adenophyllum, Michelia champaca, and Tectona grandis. From a literature search for reports on the chemical constituents of these plants, most constituents were found to be quinone derivatives or other compounds with unsaturated carbonyl groups.