Evaluating the temporal context of episodic memory: The role of CA3 and CA1
Evaluating the temporal context of episodic memory: The role of CA3 and CA1
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DOI：
10.1016/j.bbr.2007.11.015
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发表时间：
2008-04-09
影响因子：
2.7
通讯作者：
Kesner, Raymond P.
中科院分区：
文献类型：
--
作者：
Hunsaker, Michael R.;Lee, Bart;Kesner, Raymond P.
有研究表明，海马体介导了包括快照记忆和时间序列学习在内的情景记忆加工。来验证这个理论。老鼠学会了沿着跑道盒子的空间位置序列，并通过移除序列中的一个位置并让老鼠选择正确的位置来获得奖励来测试记忆。一旦动物能够可靠地完成这个情景记忆任务，它们就会接受CA3或CA1的损伤。CA3或CA1受损的动物在情景记忆处理方面有困难，尽管CA1受损的动物有更大的缺陷。然而，当动物接受同样任务的非情节版本的训练时，海马损伤没有影响。这些结果表明，CA3和CA1都有助于情景记忆加工，因为CA3或CA1的损伤导致无法处理情景性空间信息，而它们对非情景性信息加工没有影响。(C) 2007 Elsevier B.V.版权所有
It has been suggested that the hippocampus mediates episodic memory processing involving snapshot memory and temporal sequence learning. To test this theory. rats learned trial-unique sequences of spatial locations along a runway box and were tested on recall by removing one of the locations in the sequence and making the rat choose the correct location to be rewarded. Once animals were able to reliably perform this episodic memory task, they received lesions to either CA3 or CA1. Animals with lesions to either CA3 or CA1 had difficulty with episodic memory processing, although CA1 lesioned animals had a much greater deficit. However, when animals were trained on a non-episodic version of the same task, hippocampal lesions had no effect. These results suggest that CA3 and CA1 both contribute to episodic memory processing since lesions to CA3 or CA1 result in an inability to process spatial information episodically, whereas they have no effect on non-episodic information processing. (C) 2007 Elsevier B.V. All rights reserved.