Nitrous Oxide Effects on Cerebral Evoked Potential to Pain: Partial Reversal with a Narcotic Antagonist
Nitrous Oxide Effects on Cerebral Evoked Potential to Pain: Partial Reversal with a Narcotic Antagonist
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一氧化二氮对大脑疼痛诱发电位的影响：麻醉拮抗剂部分逆转
DOI：
10.1097/00000542-197908000-00009
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发表时间：
1979
期刊：
影响因子：
8.8
通讯作者：
C. Benedetti
中科院分区：
文献类型：
--
作者：
C. Chapman;C. Benedetti
在12名志愿者中研究了0.4 mg纳洛酮对33%的一氧化二氮在氧气中诱导的镇痛作用的影响。动物实验结果表明内源性阿片样物质可能在笑气镇痛机制中起主要作用，但在人的实验中尚未发现这一点.本实验在吸入笑气前、后及笑气加纳洛酮0.4mg一次后，记录痛性牙髓电刺激的脑诱发电位（CEP）;吸入室内空气前后及吸入室内空气后加纳洛酮0.4mg。在80和350毫秒之间观察到的CEP波形在三个峰-峰振幅和峰值延迟方面进行量化。一氧化二氮使每个波形的峰-峰幅度降低48%，纳洛酮使100 ~ 175毫秒的负向波的峰-峰幅度恢复。一氧化二氮也增加了175毫秒的负峰潜伏期，纳洛酮将此峰潜伏期恢复至正常水平。室内空气或室内空气加纳洛酮均不改变CEP振幅或波幅。随着时间的推移，一氧化二氮的疼痛强度降低和纳洛酮的疼痛部分增加的主观报告的显著趋势是明显的。这些发现表明，一氧化二氮对中枢神经系统的一些影响可以被纳洛酮逆转。
The effect of naloxone, 0.4 mg, on the analgesia induced by nitrous oxide, 33 per cent, in oxygen, was studied in 12 volunteers. Results of previous investigations in animals suggested that endogenous opiate-like substances may play a major role in the analgesic mechanism of nitrous oxide, but the issue had not been studied in man. Cerebral evoked potentials (CEP) to painful tooth-pulp electrical shocks were obtained before and after inhalation of nitrous oxide, and after nitrous oxide plus naloxone, 0.4 mg, in one session; and before and after inhalation of room air, and after room air plus naloxone, 0.4 mg, in another session. CEP waveforms observed between 80 and 350 msec were quantified in terms of three peak-to-peak amplitudes and peak latencies. Nitrous oxide decreased each of the waveform peak-to-peak amplitudes 48 per cent. Naloxone restored the peak-to-peak amplitude of the negative-going wave occurring between 100 and 175 msec. Nitrous oxide also increased the negative peak latency at 175 msec, and naloxone restored this peak latency to normal levels. Neither room air nor room air plus naloxone altered CEP amplitudes or latencies. Over time a significant trend in subjective reports of decreased pain intensity with nitrous oxide and partially increased pain with naloxone was evident. These findings demonstrate that some of the effects of nitrous oxide on the central nervous system can be reversed by naloxone.