Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus
Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus
复制标题
五种灵芝（伞形孢菌）对与 2 型糖尿病相关的关键消化酶的抑制作用
DOI：
10.1615/intjmedmushrooms.v21.i7.70
复制
发表时间：
2019-01-01
影响因子：
1.2
通讯作者：
Xie, Yi-Zhen
中科院分区：
文献类型：
--
作者：
Chen, Shao-Dan;Yong, Tian-Qiao;Xie, Yi-Zhen
Ganoderma mushrooms are widely used in clinical therapies and functional foods. The antidiabetic effect of Ganoderma has become a research hot spot in recent decades. To search for a superior antidiabetic Ganoderma extract, five common Ganoderma species (G. lucidum, G. sinense, G. tsugae, G. applanatum, and G. leucocontextum) were investigated. A total of 10 fractions, including a total triterpenes fraction and a crude polysaccharides fraction for each, were prepared for further assays. Activities of alpha-glucosidase and alpha-amylase are inhibited dominantly by triterpenes from all five Ganoderma species rather than the polysaccharides. G. lucidum triterpenes inhibits alpha-glucosidase and alpha-amylase most significantly with IC50 values of 10.02 +/- 0.95 mu g/mL and 31.82 +/- 4.30 mu g/mL. Even more, triterpenes content was positively correlated with anti-alpha-glucosidase and anti-alpha-amylase activities. Therefore, triterpenes were considered to be the active compounds in inhibiting alpha-glucosidase and alpha-amylase activity. It is hoped that the results will provide more systematic information for the application of Ganoderma in the functional food and traditional medicine industries in the future.
