PROGRESSIVE RATIO AND FIXED-RATIO SCHEDULES OF COCAINE-MAINTAINED RESPONDING IN BABOONS
PROGRESSIVE RATIO AND FIXED-RATIO SCHEDULES OF COCAINE-MAINTAINED RESPONDING IN BABOONS
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DOI：
10.1007/bf00433038
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发表时间：
1979-01-01
影响因子：
3.4
通讯作者：
BRADY, JV
中科院分区：
文献类型：
--
作者：
GRIFFITHS, RR;BRADFORD, LD;BRADY, JV
那些由实验动物自身注射的化合物与那些在人类中经常被滥用的化合物之间存在对应关系。响应保持在静脉注射的累进比率(PR)和固定比率(FR 160)时间表下。研究了恒河猴注射生理盐水或可卡因(0.01-4.0 mg/kg)。每次注射后都有一个超时周期，即PR方案为3h，FR方案为3h或12h。在PR计划中，比例要求每天都在系统地增加，直到达到自我注射性能低于标准水平(每天1次或0次注射)的临界点。公关计划的总体应答率随着比率的逐步增加而增加，直到出现应答率突然减少的最大值。在暂停3h后，PR计划上的剂量断裂点函数与FR计划上的剂量-效应率函数相似。剂量-效应曲线呈倒U型曲线，呈递增趋势(0.01-0.32 mg/kg)，最高剂量(3.0-4.0 mg/kg)呈下降趋势。在FR方案中，剂量-反应率功能的下降可归因于累积药物效应，如操纵超时持续时间和分析连续反应间隔时间分布和累积反应记录所揭示的那样。PR和FR时间表提供了关于不同剂量可卡因的相对增强效果的类似信息。
There is a correspondence between those compounds that are self-injected by laboratory animals and those that are commonly abused in humans. Responding maintained under progressive ratio (PR) and fixed ratio (FR 160) schedules of i.v. saline or cocaine (0.01-4.0 mg/kg) injections was studied in baboons. Each injection was followed by a time-out period which was 3 h with the PR schedule and was either 3 or 12 h with the FR schedule. On the PR schedule the ratio requirement was systematically increased each day until reaching the breaking point at which self-injection performance fell below a criterion level (1 or zero injections per day). Overall response rates on the PR schedule increased with progressive increases in the ratio until a maximum at which an abrupt reduction in responding occurred. With the 3 h time-out the dose-breaking point function on the PR schedule was similar to the dose-response rate function on the FR schedule. These dose-effect functions were inverted U-shaped curves characterized by a graded ascending limb (0.01-0.32 mg/kg) and a downturn at the highest doses (3.0-4.0 mg/kg). On the FR schedule the downturn in the dose-response rate function was attributable to a cumulative drug effect as revealed by manipulatin of time-out duration and analysis of sequential interresponse time distributions and cumulative response records. PR and FR schedules provide similar information about the relative reinforcing efficacy of different cocaine doses.