SYSTEMIC ALTERATION INDUCED IN MICE BY UV LIGHT IRRADIATION AND ITS RELATIONSHIP TO UV CARCINOGENESIS
SYSTEMIC ALTERATION INDUCED IN MICE BY UV LIGHT IRRADIATION AND ITS RELATIONSHIP TO UV CARCINOGENESIS
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DOI：
10.1073/pnas.74.4.1688
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发表时间：
1977-01-01
影响因子：
11.1
通讯作者：
KRIPKE, ML
中科院分区：
文献类型：
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作者：
FISHER, MS;KRIPKE, ML
用紫外线对小鼠进行慢性照射会产生免疫学性质的全身性改变。这种变化在小鼠中是可检测的，在由紫外线诱导的原发性皮肤癌开始出现之前。这种改变导致UV照射的小鼠不能排斥高抗原性的、移植的UV诱导的肿瘤，而这些肿瘤被未照射的同基因受体排斥。这种系统性改变的免疫学方面的表现，从紫外线照射小鼠淋巴细胞转移到致命的X射线照射的收件人。这些受者不能抵抗随后的同源UV诱导的肿瘤的挑战，而那些给予来自正常供体的淋巴细胞的受者对肿瘤生长具有抗性。正常小鼠与UV照射的小鼠的共生，随后用UV诱导的肿瘤对两种共生体进行肿瘤攻击，导致UV照射和未照射的小鼠中攻击肿瘤的生长。脾淋巴细胞从肿瘤植入紫外线治疗的小鼠在体外对紫外线诱导的肿瘤没有细胞毒性，而在相同的条件下，细胞从肿瘤植入，未经照射的小鼠细胞毒性。重复UV照射可以规避免疫机制，否则可能会破坏新生的UV诱导的原发性肿瘤是强抗原性的。
Chronic irradiation of mice with UV light produces a systemic alteration of an immunologic nature. This alteration is detectable in mice before primary skin cancers induced by UV light begin to appear. The alteration results in the failure of UV irradiated mice to reject highly antigenic, transplanted UV induced tumors that are rejected by unirradiated syngeneic recipients. The immunologic aspect of this systemic alteration was demonstrated by transferring lymphoid cells from UV irradiated mice to lethally X-irradiated recipients. These recipients were unable to resist a later challenge with a syngeneic UV induced tumor, whereas those given lymphoid cells from normal donors were resistant to tumor growth. Parabiosis of normal mice with UV irradiated mice, followed by tumor challenge of both parabionts with a UV induced tumor, resulted in growth of the challenge tumors in UV irradiated and unirradiated mice. Splenic lymphocytes from tumor implanted UV treated mice were not cytotoxic in vitro against UV induced tumors, whereas under identical conditions cells from tumor implanted, unirradiated mice were cytotoxic. Repeated UV irradiation can circumvent an immunologic mechanism that might otherwise destroy nascent UV induced primary tumors that are strongly antigenic.