Highly targeted cholera vaccination campaigns in urban setting are feasible: The experience in Kalemie, Democratic Republic of Congo
Highly targeted cholera vaccination campaigns in urban setting are feasible: The experience in Kalemie, Democratic Republic of Congo
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DOI：
10.1371/journal.pntd.0006369
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发表时间：
2018-05-01
影响因子：
3.8
通讯作者：
Luquero, Francisco
中科院分区：
文献类型：
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作者：
Massing, Louis Albert;Aboubakar, Soumah;Luquero, Francisco
口服霍乱疫苗主要是世界卫生组织推荐用于流行国家的霍乱控制。然而，目前生产的霍乱疫苗数量非常有限，在流行国家，特别是在城市环境中使用OCV的例子很少。医师无国界协会和卫生部在刚果民主共和国的一个高度流行地区组织了一次疫苗接种运动。本研究的目的是描述这种高度针对性的疫苗接种运动和接受接种community.Methods和findingsWe之间实现的疫苗覆盖率进行了横断面调查，采用随机空间抽样。研究人群包括1岁及以上、符合接种条件、居住在卡莱米市接种目标地区的个体。数据来源为家庭访谈，并通过疫苗接种卡进行验证。共有2,488人参加了调查。总体而言，81.9%（95% CI：77.9-85.3）的目标人群至少接种了一剂疫苗。两剂次接种率为67.2%（95%CI：61.9-72.0）。第一轮疫苗接种率（74.0，95% CI：69.3-78.3）高于第二轮疫苗接种率（69.1%，95% CI：63.9-74.0）。成年男性的疫苗接种率较低。不接种疫苗的主要原因是在运动期间缺席。没有严重的不良事件被通知在interventions.ConclusionsCholera疫苗接种运动，使用高度针对性的策略是可行的，在城市环境。通过挨家挨户接种疫苗，可实现高疫苗接种覆盖率。然而，应考虑替代战略，以覆盖未接种疫苗的人群，如成年男性，并提高干预措施的效率。
IntroductionOral cholera vaccines are primarily recommended by the World Health Organization for cholera control in endemic countries. However, the number of cholera vaccines currently produced is very limited and examples of OCV use in endemic countries, and especially in urban settings, are scarce. A vaccination campaign was organized by Medecins Sans Frontieres and the Ministry of Health in a highly endemic area in the Democratic Republic of Congo. This study aims to describe the vaccine coverage achieved with this highly targeted vaccination campaign and the acceptability among the vaccinated communities.Methods and findingsWe performed a cross-sectional survey using random spatial sampling. The study population included individuals one year old and above, eligible for vaccination, and residing in the areas targeted for vaccination in the city of Kalemie. Data sources were household interviews with verification by vaccination card. In total 2,488 people were included in the survey. Overall, 81.9% (95% Cl: 77.9-85.3) of the target population received at least one dose of vaccine. The vaccine coverage with two doses was 67.2% (95%Cl: 61.9-72.0) among the target population. The vaccine coverage was higher during the first round (74.0, 95% Cl: 69.3-78.3) than during the second round of vaccination (69.1%, 95% Cl: 63.9-74.0). Vaccination coverage was lower in male adults. The main reason for non-vaccination was to be absent during the campaign. No severe adverse events were notified during the interviews.ConclusionsCholera vaccination campaigns using highly targeted strategies are feasible in urban settings. High vaccination coverage can be obtained using door to door vaccination. However, alternative strategies should be considered to reach non-vaccinated populations like male adults and also in order to improve the efficiency of the interventions.