A longitudinal study of a patient with acquired immunodeficiency syndrome using T cell subset analysis.
A longitudinal study of a patient with acquired immunodeficiency syndrome using T cell subset analysis.
复制标题
使用 T 细胞子集分析对患有获得性免疫缺陷综合征的患者进行的纵向研究。
DOI：
10.1007/978-1-4757-1410-4_25
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发表时间：
1983
影响因子：
--
通讯作者：
Fox,RW
中科院分区：
文献类型：
--
作者：
Siegel,RL;Fox,RW
疾病控制中心在1981年报告了一个流行病的肺囊虫肺炎和卡波西肉瘤的年轻以前健康的同性恋男子（1，2）。已经发表了其他报告，确定了该患者组和其他患者组中的病毒、细菌、真菌和原生动物感染（3-5）。临床观察和免疫学评估确定了这些患者的获得性免疫缺陷综合征（AIDS）（3-7）。在许多描述的最初病例中，发现了五个主要特征：机会性感染（1），如卡氏肺孢子虫肺炎，卡波西肉瘤（2），巨细胞病毒感染（3），娱乐性药物使用（4），同性恋或双性恋活动（5）。这些报告中有几份提供了这些患者中获得性T细胞缺陷的证据。这些患者通常是无反应性，淋巴细胞减少，并减少淋巴细胞增殖有丝分裂原和抗原在体外。外周血T细胞群的分析显示T辅助/诱导细胞群（Leu 3+或OKT 4+）亚群的数量减少，T抑制/细胞毒性细胞（Leu 2+或OKT 8+）的百分比增加（3，6，7）。这些研究没有报道在疾病过程中T细胞亚群的任何变化。因此，我们使用T细胞亚群分析对患有该综合征的患者进行了为期四个月的纵向研究。
The Centers for Disease Control in 1981 reported an epidemic of Pneumocystis carinii pneumonia and Kaposi's sarcoma in young previously healthy homosexual men (1, 2). Additional reports have been published identifying viral, bacterial, fungal, and protozoan infections in this and other patient groups (3-5). Clinicalobservations and immunologic evaluations have defined an Acquired Immunologic Deficiency Syndrome (AIDS) in these patients (3-7).In many of the initial cases described, five major features were found. They were opportunistic infections (1), such as Pneumocystis carlnll pneumonia, Kaposi's sarcoma (2), cytomegalovirus infections (3), recreational drug use (4), and homosexual or bisexual activities (5). Several of these reports have presented evidence for an acquired T cell defect in these patients. These patients are usually anergic, lymphopenic, and have decreased lymphocyte proliferation to mitogens and antigens in vitro. Analysis of peripheral blood T cell populations has revealed decreased numbers of the T helper/inducer population (Leu 3+ or OKT4+) subset and an increased percentage of T suppressor/cytotoxic cells (Leu 2+ or OKT8+)(3, 6, 7). These studies have not reported any changes in T cell subsets during the course of the disease. Thus, we undertook a four month longitudinal study of a patient with this syndrome using T cell subset analysis.