Coenzyme AdoB12 vs AdoB12.-homolytic Co-C cleavage following electron transfer: a rate enhancement greater than or equal to 10(12).
Coenzyme AdoB12 vs AdoB12.-homolytic Co-C cleavage following electron transfer: a rate enhancement greater than or equal to 10(12).
复制标题
辅酶 AdoB12 与 AdoB12.-电子转移后的均质 Co-C 裂解：速率增强大于或等于 10(12)。
DOI：
10.1016/0162-0134(90)80036-w
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发表时间：
1990
影响因子：
3.9
通讯作者：
Martin,BD
中科院分区：
文献类型：
--
作者：
Finke,RG;Martin,BD
腺苷钴胺素的25°C Co → C键均裂速率常数的比较（辅酶B_（12））与电化学还原的腺苷钴胺素自由基阴离子相比，加入一个反键电子后，速率至少提高1012± 2。基于四条证据，腺苷钴胺素依赖性酶反应中Co γ C均裂的电子转移活化被认为是不可能的。
Comparison of the 25°C CoC bond homolysis rate constant of adenosyl-cobalamin (coenzyme B12) vs that for electrochemically reduced adenosyl-cobalamin radical anion indicates a rate enhancement of at least 1012±2upon the addition of one antibonding electron. Even though electrochemical reduction promotes CoC homolysis by virtually the same amount as the 1012±2enzymic activation seen for adenosylcobalamin, electron-transfer activation of the CoC homolysis in adenosylcobalamin-dependent enzyme reactions is considered unlikely, based on four lines of evidence.