Biochemistry and Cell Biology of Ageing: Part II Clinical Science
Biochemistry and Cell Biology of Ageing: Part II Clinical Science
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衰老的生物化学和细胞生物学：第二部分临床科学
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
V. Korolchuk
中科院分区：
文献类型：
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作者：
V. Korolchuk
The prevalence of age-associated disease is increasing at a striking rate globally and there is evidence to suggest that the ageing process may actually begin before birth. It has been well-established that the status of both the maternal and early postnatal environments into which an individual is exposed can have huge implications for the risk of developing age-associated disease, including cardiovascular disease (CVD), type-2 diabetes (T2D) and obesity in later life. Therefore, the dissection of underlying molecular mechanisms to explain this phenomenon, known as ‘developmental programming’ is a highly investigated area of research. This book chapter will examine the epidemiological evidence and the animal models of suboptimal maternal and early postnatal environments and will discuss the progress being made in the development of safe and effective intervention strategies which ultimately could target those ‘programmed’ individuals who are known to be at-risk of age-associated disease.
