Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health Initiative
Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health Initiative
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DOI：
10.1038/ejcn.2011.207
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发表时间：
2012-05-01
影响因子：
4.7
通讯作者：
Rohan, T. E.
中科院分区：
文献类型：
--
作者：
Kabat, G. C.;Kim, M. Y.;Rohan, T. E.
背景/目的：以前的队列研究检查了血清抗氧化剂水平和结直肠癌风险之间的关系，仅使用了单一（基线）测量。在本研究中，我们采用重复测量的方法，评估了8种抗氧化营养素的血清水平与结直肠癌风险之间的关系。妇女健康倡议中妇女的子样本数据，重复测量血清视黄醇、α-胡萝卜素、β-胡萝卜素、β-隐黄质、叶黄素+玉米黄质、番茄红素，随访期间的α-生育酚和γ-生育酚也包括在分析中。考克斯比例风险模型被用来估计风险比（HR）和95%的置信区间（CIs）。结果：在5477名基线血清抗氧化值的妇女中，88例大肠癌的发病病例被确定在一个中位随访时间为12年。基线时测量的血清抗氧化剂通常与结直肠癌风险无关，尽管基线时血清β-胡萝卜素与结肠癌单独呈非显著负相关。此外，使用β-胡萝卜素的重复测量，所有测量的平均值与结直肠癌和结肠癌的风险呈负相关：最高与最低三分位数的HR分别为0.54，95%CI 0.31-0.96和0.47，95%CI 0.25-0.88。在重复测量analysis.Conclusions：在这项研究中，抗氧化营养素的基线水平与结直肠癌或结肠癌的风险无关;然而，使用重复测量，相对较高的血清β-胡萝卜素水平（所有测量的平均值）与绝经后妇女的结肠和结直肠癌风险呈负相关。欧洲临床营养学杂志（2012）66，549-554; doi：10.1038/ejcn.2011.207; 2011年12月14日在线发表
Background/Objective: Previous cohort studies examining the association of serum antioxidant levels and risk of colorectal cancer have used a single (baseline) measurement only. In the present study, we assessed the association of serum levels of eight antioxidant nutrients in relation to risk of colorectal cancer, using repeated measurements.Subjects/Methods: Data on a subsample of women in the Women's Health Initiative with repeated measurements of serum retinol, alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin, lycopene, alpha-tocopherol and gamma-tocopherol during follow-up were included in the analysis. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CIs).Results: Among 5477 women with baseline serum antioxidant values, 88 incident cases of colorectal cancer were identified over a median follow-up time of 12 years. Serum antioxidants measured at baseline generally showed no association with risk of colorectal cancer, although serum beta-carotene at baseline showed a non-significant inverse association with colon cancer alone. Furthermore, using the repeated measurements of beta-carotene, the average of all measurements was inversely associated with risk of both colorectal and colon cancer: HRs for highest vs lowest tertile 0.54, 95% CI 0.31-0.96, and 0.47, 95% CI 0.25-0.88, respectively. No associations were seen with other antioxidant nutrients in the repeated measure analyses.Conclusions: In this study, baseline levels of antioxidant nutrients were not associated with risk of colorectal or colon cancer; however, using repeated measures, a relatively high serum level of beta-carotene (average of all measurements) was inversely associated with risk of colon and colorectal cancer in postmenopausal women. European Journal of Clinical Nutrition (2012) 66, 549-554; doi:10.1038/ejcn.2011.207; published online 14 December 2011