Zonal Growth Pattern of the Prostate Is Affected by Age and Body Mass Index.
Zonal Growth Pattern of the Prostate Is Affected by Age and Body Mass Index.
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前列腺的区域生长模式受年龄和体重指数的影响。
DOI：
10.1097/ju.0000000000002332
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Olumi,AriaF
中科院分区：
文献类型：
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作者：
Sharkey,Christina;Long,Xingbo;Wang,Zongwei;Al-Faouri,Ra'ad;Gershman,Boris;Tsai,LeoL;Olumi,AriaF
目的随着男性年龄的增长，前列腺继续以平均每年 2.5% 的速度增长。虽然人们认识到总前列腺的生长速度存在差异，但不同前列腺区域的生长速度仍不清楚。我们评估了前列腺区域的生长模式，并确定了影响区域生长率的临床参数。材料和方法回顾性地获得了 2003 年至 2018 年间至少接受过 3 次前列腺 MRI 的 156 名患者的前列腺磁共振成像 (MRI) 数据和临床信息。测量和分析了不同的前列腺区域体积。使用线性回归分析结果。结果我们观察到，前列腺生长率根据体重指数 (BMI)、过渡区指数 (TZI)、前列腺区和 5-α 还原酶抑制剂 (5ARI) 的使用而变化。周边区体积增长率随着年龄的增长而增加，并在 60-70 岁达到峰值 (p=0.047)，而过渡区体积在所有年龄段都表现出持续增长，但没有出现峰值。 BMI 和 TZI 与周边区的增长率相关（分别为 p=0.026，p <0.001），但与过渡区的增长率无关。 5ARI 的使用与过渡区增长率的降低显着相关 (p=0.033)，而不是外围区。此外，TZI 大于 60% 的患者在服用 5ARI 时，移行区生长率降低最为显着 (p <0.001)。 结论 前列腺移行区和周围区的生长速度各不相同。 BMI 和 TZI 影响周边区生长速率，而 5ARI 的使用会降低过渡区生长速率。
PurposeAs men age, the prostate continues to grow on average 2.5% per year. While the variable growth rate of the total prostate gland is recognized, the growth rate of different prostate zones remains largely unclear. We evaluated the growth patterns of the prostate zones and identified clinical parameters contributing to the zonal growth rates.Materials and MethodsProstate magnetic resonance imaging (MRI) data and clinical information were obtained retrospectively on 156 patients who had at least 3 prostate MRIs between 2003 and 2018. Different prostate zonal volumes were measured and analyzed. The outcome was analyzed using linear regression.ResultsWe observed that prostate growth rates vary depending on body mass index (BMI), transition zone index (TZI), the prostate zone and 5-alpha reductase inhibitor (5ARI) use. The peripheral zone volume growth rates increased with age and peaked at 60–70 years of age (p=0.047), while the transition zone volume demonstrates continuous growth without a peak through all ages. BMI and TZI are associated with the growth rate of the peripheral zone (p=0.026, p <0.001, respectively) but not the transition zone growth rate. 5ARI use is significantly associated with the reduction in the transition zone growth rate (p=0.033), not the peripheral zone. In addition, patients with TZI greater than 60% had the most significant reduction in the transition zone growth rate while taking 5ARI (p <0.001).ConclusionsTransition and peripheral zones of the prostate grow at variable rates. BMI and TZI affect peripheral zone growth rate, while 5ARI use reduces the transition zone growth rate.