A polymorphism in an autophagy-related gene, ATG16L1, influences time to delivery in women with an unfavorable cervix who require labor induction
A polymorphism in an autophagy-related gene, ATG16L1, influences time to delivery in women with an unfavorable cervix who require labor induction
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DOI：
10.1515/jpm-2012-0278
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发表时间：
2013-07-01
影响因子：
2.4
通讯作者：
Witkin, Steven S.
中科院分区：
文献类型：
--
作者：
Doulaveris, Georgios;Orfanelli, Theofano;Witkin, Steven S.
自噬是一种细胞内过程，通过清除受损的细胞器和蛋白质来维持体内平衡。自噬相关的16-like 1（ATG 16 L1）基因中的单核苷酸多态性（SNP）导致自噬减少。我们评估了ATG 16 L1基因多态性是否影响宫颈不良孕妇在引产期间的分娩时间。来自69名因过期妊娠而需要引产的子宫颈不良妇女的DNA（> 294天）（n = 26），羊水过少（n = 17），高血压或先兆子痫（n = 10），胎心率异常（n = 8），糖尿病（n = 3）或其他原因（n = 5）的患者通过基因扩增和内切酶消化来检测ATG 16 L1（rs 2241880）中的SNP。A，A纯合子女性从引产到分娩的平均时间（SD）为20.8（9.7）小时，A，G杂合子女性为19.2（8.8）小时，G，G变体纯合子携带者为14.3（6.6）小时（P = 0.03 A，A vs. G，G，P = 0.04 A，A/A，G vs. G，G）。分娩时间>= 24和> 24 h的孕妇G、G患病率分别为24.4%和4.2%（P = 0.04）。诱导适应症的基因型分布无差异。自噬的遗传能力降低可能对子宫颈不好的妇女有益，因为她们必须引产。
Autophagy is an intracellular process that maintains homeostasis by the removal of damaged organelles and proteins. A single nucleotide polymorphism (SNP) in the autophagy-related 16-like 1 (ATG16L1) gene results in decreased autophagy. We evaluated whether the ATG16L1 polymorphism influenced the time to delivery during labor induction in pregnant women with an unfavorable cervix. DNA from 69 women with an unfavorable cervix who required labor induction due to post-term (> 294 days) (n = 26), oligohydramnios (n = 17), hypertension or pre-eclampsia (n = 10), abnormal fetal heart rate (n = 8), diabetes (n = 3) or other reasons (n = 5) was tested by gene amplification and endonuclease digestion for a SNP in ATG16L1 (rs2241880). The mean hours (SD) from induction to delivery was 20.8 (9.7) for women who were A, A homozygotes, 19.2 (8.8) for A, G heterozygotes and 14.3 (6.6) for homozygote carriers of the G, G variant (P = 0.03 A, A vs. G, G, P = 0.04 A, A/A, G vs. G, G). The G, G prevalence was 24.4% and 4.2% for those who delivered in >= 24 and > 24 h, respectively (P = 0.04). There was no difference in genotype distribution by indication for induction. A decreased genetic capacity for autophagy may be beneficial in women with an unfavorable cervix whose labor has to be induced.