Impact of Donor Age on the Outcome of Living-donor Liver Transplantation: Special Consideration to the Feasibility of Using Elderly Donors
Impact of Donor Age on the Outcome of Living-donor Liver Transplantation: Special Consideration to the Feasibility of Using Elderly Donors
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DOI：
10.1097/tp.0000000000003246
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发表时间：
2021-02-01
期刊：
影响因子：
6.2
通讯作者：
Hibi, Taizo
中科院分区：
文献类型：
--
作者：
Kadohisa, Masashi;Inomata, Yukihiro;Hibi, Taizo
背景：在活体供肝移植(LDLT)中使用老年供者(年龄=60岁)仍然存在争议。方法：回顾1998年12月至2017年3月熊本大学医院470例同种异体原位肝移植的临床资料。结果：供者按年龄分为5组：20~29岁109例，30~39岁157例，40~49岁87例，50~59岁81例，>；60例。在我们机构，老年捐赠者候选人需要额外的术前检查。5组供者术后并发症发生率及术后住院天数差异无统计学意义。不考虑移植物类型，老年供者与年轻供者组相当(=60岁可以安全地被选为LDLT供者，经过细致的术前检查。
Background.The use of elderly donors (>= 60 y) in living-donor liver transplantation (LDLT) remains controversial. In this study, we aimed to determine the safety of surgery for elderly donors and the impact of donor age on LDLT outcomes.Methods.We, retrospectively, reviewed 470 cases of LDLT at Kumamoto University Hospital from December 1998 to March 2017.Results.Donors were divided into 5 groups according to age: 20-29 (n = 109), 30-39 (n = 157), 40-49 (n = 87), 50-59 (n = 81), and >= 60 (n = 36). At our institution, elderly donor candidates required additional preoperative work-up. There were no significant differences in the incidence of postoperative complications and duration of postoperative hospital stay among the 5 donor groups. Regardless of graft type, elderly donors were comparable to younger donor groups (= 60 years of age can safely be selected as LDLT donors after meticulous preoperative work-up.