MicroRNAs in cardiac development and remodeling.
MicroRNAs in cardiac development and remodeling.
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MicroRNA 在心脏发育和重塑中的作用。
DOI：
10.1007/s00246-010-9641-9
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发表时间：
2010
影响因子：
1.6
通讯作者：
Wang,Da-Zhi
中科院分区：
文献类型：
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作者：
Wang,Da-Zhi
microRNA（miRNAs）是一类高度保守的非编码小RNA，在生物学过程中发挥重要作用。miRNA表达失调与人类心血管疾病有关，使用动物模型的研究表明，miRNA对心脏发育和重塑至关重要。这些以前未被识别的小分子揭示了心脏发育和病理学基础的调控机制，表明miRNA作为心血管疾病的诊断标志物和治疗靶点的潜在重要性。
MicroRNAs (miRNAs) are a class of highly conserved, small, noncoding RNAs that play roles in a wide range of biologic processes. Dysregulated miRNA expression has been associated with human cardiovascular disease, and studies using animal models have shown that miRNAs are essential for cardiac development and remodeling. These previously unrecognized small molecules shed new light on the regulatory mechanisms underlying cardiac development and pathology, suggesting the potential importance of miRNAs as diagnostic markers and therapeutic targets for cardiovascular disease.