Neurocognitive performance in patients with depression compared to healthy controls: Association of clinical variables and remission state
Neurocognitive performance in patients with depression compared to healthy controls: Association of clinical variables and remission state
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DOI：
10.1016/j.psychres.2018.11.047
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发表时间：
2019-01
影响因子：
11.3
通讯作者：
Thea Marianne Grützner;Anuradha Sharma;Lena Listunova;M. Bartolovic;M. Weisbrod;D. Roesch-Ely
中科院分区：
文献类型：
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作者：
Thea Marianne Grützner;Anuradha Sharma;Lena Listunova;M. Bartolovic;M. Weisbrod;D. Roesch-Ely
重性抑郁症（MDD）的认知功能障碍被认为会持续到缓解期。然而，不一致的定义，临床缓解，模式和影响因素，孤立的认知任务，以及缺乏适当匹配的控制（HC）目前显着的局限性，以前的研究。此外，调查部分缓解患者的认知能力的研究特别少。本研究比较了MDD患者（N= 65）和HC（N= 65）的认知，通过年龄，性别和教育（年龄19-60）的一对一招募策略进行匹配。通过广泛的NPS测试组合测量神经心理学（EEG）表现，并进行回顾性分析，考虑人口统计学和临床变量。完全缓解定义为HAMD临界值≤7，部分缓解定义为HAMD 8-18。研究结果显示，与HC相比，整个MDD组和部分缓解的MDD具有显著更差的抗抑郁性能，而缓解的MDD患者与HC没有显著差异。这强调了缓解的明确定义对于比较MDD研究的重要性。临床变量“住院次数”对认知有显著影响，而当前症状严重程度与任何认知领域的表现无关。较高的住院次数可能与较高的疾病负担和较大的神经生物学“疤痕效应”有关。
Cognitive impairment in Major Depressive Disorder (MDD) has been postulated to persist into remission. However, inconsistent definitions of clinical remission, patterns and influencing factors, isolated cognitive tasks, and the lack of appropriately matched controls (HCs) present significant limitations of previous studies. Furthermore, studies investigating cognition in partially remitted patients are particularly scarce. This study compares the cognition of MDD patients (N= 65) and HCs (N= 65), matched by one-to-one recruitment strategy for age, sex, and education (ages 19–60). The neuropsychological (NPS) performance was measured via an extensive NPS-test battery and analysed retrospectively, accounting for demographic and clinical variables. Full remission was defined as HAMD cut off ≤7, partial remission as HAMD 8–18. The findings show entire MDD group and partially remitted MDD with significantly poorer NPS performance compared to HCs, while remitted MDD patients did not differ significantly from HCs. This underscores how critical a clear definition of remission is to compare studies on MDD. The clinical variable ‘number of hospitalizations’ had a significant effect on cognition, whereas current symptom severity did not correlate with performance on any cognitive domain. Higher number of hospitalizations may be associated with higher burden of illness and greater neurobiological “scar effects”.