Association between sex hormones and ambulatory blood pressure.
Association between sex hormones and ambulatory blood pressure.
复制标题
性激素与动态血压之间的关联。
DOI：
10.1097/hjh.0000000000001812
复制
发表时间：
2018
影响因子：
4.9
通讯作者：
Sesso,HowardD
中科院分区：
文献类型：
--
作者：
Jiménez,MonikC;Wang,Lu;Buring,JulieE;Manson,JoAnnE;Forman,JohnP;Sesso,HowardD
Methods:Baseline blood samples were assayed for 229 normotensive men (≥ 50 years) and women (≥ 55 years) participating in the VITamin D and OmegA-3 TriaL. Standardized seated BP (SBP and DBP) and 24-h ABP were measured by trained technicians. Self-reported cardiovascular risk factors and sociodemographic variables were reported on baseline questionnaires. Sex stratified linear regression models adjusted for age, race/ethnicity, BMI, smoking and alcohol estimated the association between each sex hormone and measures of BP and 24-h ABP. Logistic regression used to estimate associations with blunted nocturnal decline (> 10% reduction in SBP or DBP during sleeping hours).Results:Total testosterone and SHBG demonstrated significant inverse correlations with SBP whereas DHEAS was not significantly associated with BP. Among men, in multivariable analyses, each 10% increase in DHEAS was associated with a 0.41 mmHg higher seated DBP (β= 4.29, 95% CI 0.84− 7.73) and each 10% increase in total testosterone and SHBG was associated with a 0.54 mmHg (β=− 5.65, 95% CI− 10.45 to− 0.84) and 0.60 mmHg (β=− 6.30, 95% CI− 11.38 to− 1.21) decrease in seated DBP, respectively. No significant associations were observed among women.Conclusion:Among men only, we observed statistically significant inverse cross-sectional associations between total testosterone and SHBG with seated DBP, and a significant positive association with DHEAS levels.
