POSSIBLE TRANSMITTER FUNCTIONS OF ACETYLCHOLINE AND AN RFAMIDE-LIKE SUBSTANCE IN SAGITTA (CHAETOGNATHA)
POSSIBLE TRANSMITTER FUNCTIONS OF ACETYLCHOLINE AND AN RFAMIDE-LIKE SUBSTANCE IN SAGITTA (CHAETOGNATHA)
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DOI：
10.1098/rspb.1987.0007
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发表时间：
1987-02-23
期刊：
影响因子：
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通讯作者：
RYAN, KP
中科院分区：
文献类型：
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作者：
BONE, Q;GRIMMELIKHUIJZEN, CJP;RYAN, KP
箭形脉轮的运动肌纤维可能是多神经支配的，虽然有许多缝隙连接，但似乎不是电耦合的。乙酰胆碱引起运动肌肉的收缩；离子导入应用乙酰胆碱引起膜去极化和一系列类似于自发活动时的棘波。这两种作用都可被(+)-管库拉林可逆地消除。乙酰胆碱酯酶与肉瘤相关，提示乙酰胆碱可能是神经肌肉递质的候选者。免疫细胞化学研究表明，大脑和腹神经节中的许多神经元含有一种类射频胺物质。其中一些神经元与感觉器官的神经支配有关；另一些可能属于协调系统。目前，这些观察没有表明毛颌类与任何其他无脊椎动物门的亲缘关系。
The locomotor muscle fibres of the chaetognath Sagitta are probably multiply innervated and, although linked by numerous gap junctions, do not appear to be coupled electrically. Acetylcholine evokes contraction of the locomotor muscle; iontophoretic application of acetylcholine evokes membrane depolarizations and a series of spikes resembling those seen during spontaneous activity. Both effects are reversibly abolished by (+)-tubocurarine. Acetylcholinesterase is found asociated with the sarcolemmata, and it is suggested that acetylcholine is a possible candidate for the neuromuscular transmitter. Immunocytochemical studies with antisera raised against the sequence Arg-Phe-amide (RFamide) show that many neurons in the brain and ventral ganglia contain an RF amide-like material. Some of these neurons are associated with the innervation of sensory organs; others may belong to coordinating systems. At present, these observations do not indicate the affinity of the Chaetognatha to any other invertebrate phylum.