Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study
Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study
复制标题
DOI：
10.1017/s0033291708003723
复制
发表时间：
2009-03-01
影响因子：
6.9
通讯作者：
Ferrie, J. E.
中科院分区：
文献类型：
--
作者：
Gimeno, D.;Kivimaki, M.;Ferrie, J. E.
背景。由于缺乏纵向研究，很难确定诸如C反应蛋白和白细胞介素 - 6等低度慢性炎症标志物的循环浓度与抑郁症的认知症状之间关联的方向。本研究旨在评估是C反应蛋白和白细胞介素 - 6预测抑郁症的认知症状，还是这些症状预测炎症标志物。
方法。在一项针对英国白领公务员的前瞻性职业队列研究（白厅II研究）中，于1991 - 1993年基线期以及2002 - 2004年随访期测量了血清C反应蛋白、白细胞介素 - 6和抑郁症的认知症状，平均随访时间为11.8年。抑郁症症状是通过《一般健康问卷》中描述抑郁症认知症状的四个项目来测量的。根据分析的不同，参与者人数在3339到3070之间变化（平均年龄50岁，30%为女性）。
结果。基线期的C反应蛋白（β = 0.046，p = 0.004）和白细胞介素 - 6（β = 0.046，p = 0.005）可预测随访期的抑郁症认知症状，而基线期的抑郁症症状并不能预测随访期的炎症标志物。在对社会人口统计学、行为和生物学风险因素、健康状况、药物使用以及抑郁症的基线认知系统进行全面调整后，基线期的C反应蛋白（β = 0.038，p = 0.036）和白细胞介素 - 6（β = 0.041，p = 0.018）在随访期仍可预测抑郁症的认知症状。
结论。这些研究结果表明，至少就抑郁症的认知症状而言，炎症先于抑郁症出现。
Background. A lack of longitudinal studies has made it difficult to establish the direction of associations between circulating concentrations of low-grade chronic inflammatory markers, such as C-reactive protein and interleukin-6, and cognitive symptoms of depression. The present study sought to assess whether C-reactive protein and interleukin-6 predict cognitive symptoms of depression or whether these symptoms predict inflammatory markers.Method. In a prospective Occupational cohort study of British white-collar civil servants (the Whitehall II study), serum C-reactive protein, interleukin-6 and cognitive symptoms of depression were measured at baseline in 19911993 and at follow-up in 2002-2004, an average follow-up of 11.8 years. Symptoms of depression were measured with four items describing cognitive symptoms of depression from the General Health Questionnaire. The number of participants varied between 3339 and 3070 (mean age 50 years, 30% women) depending on the analysis.Results. Baseline C-reactive protein (beta=0.046, p=0.004) and interleukin-6 (beta=0.046, p=0.005) predicted cognitive symptoms of depression at follow-up, while baseline symptoms of depression did not predict inflammatory markers at follow-up. After full adjustment for sociodemographic, behavioural and biological risk factors, health conditions, medication use and baseline cognitive systems of depression, baseline C-reactive protein (beta=0.038, p=0.036) and interleukin-6 (beta=0.041, p=0.018) remained predictive of cognitive symptoms of depression at follow-up.Conclusions. These findings suggest that inflammation precedes depression at least with regard to the cognitive symptoms of depression.