OXYTOCIN ACTIVATES THE POSTPARTUM ONSET OF RAT MATERNAL-BEHAVIOR IN THE VENTRAL TEGMENTAL AND MEDIAL PREOPTIC AREAS
OXYTOCIN ACTIVATES THE POSTPARTUM ONSET OF RAT MATERNAL-BEHAVIOR IN THE VENTRAL TEGMENTAL AND MEDIAL PREOPTIC AREAS
复制标题
DOI：
10.1037/0735-7044.108.6.1163
复制
发表时间：
1994-12-01
影响因子：
1.9
通讯作者：
MASON, GA
中科院分区：
文献类型：
--
作者：
PEDERSEN, CA;CALDWELL, JD;MASON, GA
研究发现，与妊娠第 15-17 天或产后第 5-7 天相比，大鼠产中期腹侧被盖区 (VTA) 和内侧视前区 (MPOA) 的催产素结合 (B-max) 更高。在分娩过程中，通过向 VTA 或 MPOA 中输注催产素拮抗剂以及向 MPOA 中输注加压素 (V-1) 拮抗剂来阻止幼崽的取回和对幼崽采取护理姿势。这些结果暗示 VTA 和 MPOA 中的催产素以及 MPOA 中的加压素，以及在产后母亲行为激活中这些位点中催产素结合的与分娩相关的增加。
Oxytocin binding (B-max) was found to be higher in the ventral tegmental area (VTA) and the medial preoptic area (MPOA) at midparturition compared with Pregnancy Days 15-17 or Postpartum Days 5-7 in rat dams. Pup retrieval and assuming a nursing posture over pups were blocked in parturient darns by infusions of an oxytocin antagonist into the VTA or MPOA and by infusions of a vasopressin (V-1) antagonist into the MPOA. These results implicate oxytocin in the VTA and MPOA and vasopressin in the MPOA, as well as a parturition-associated rise in oxytocin binding in these sites in the postpartum activation of maternal behavior.