Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer.
Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer.
复制标题
接受卵巢癌循环化疗的女性的预期免疫抑制和恶心。
DOI：
10.1037//0022-006x.58.2.153
复制
发表时间：
1990
影响因子：
5.9
通讯作者：
Hakes,TB
中科院分区：
文献类型：
--
作者：
Bovbjerg,DH;Redd,WH;Maier,LA;Holland,JC;Lesko,LM;Niedzwiecki,D;Rubin,SC;Hakes,TB
在化疗前，医院对 20 名癌症患者的恶心和免疫功能进行了评估，并与在家中进行的评估进行了比较。从医院血液样本中分离出的细胞对 T 细胞有丝分裂原的增殖反应低于几天前获得的家庭样本。患者在医院的恶心感也增加。分层多元回归分析表明，医院免疫功能下降与焦虑增加无关。观察到的预期性免疫抑制与化疗患者在医院刺激与化疗的催吐和免疫抑制作用重复配对后可能出现条件性免疫抑制以及条件性恶心的假设是一致的。（PsycINFO数据库记录（c）2016 APA，保留所有权利）
Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.(PsycINFO Database Record (c) 2016 APA, all rights reserved)