Prevalence of human papillomavirus in inverted nasal papillomas.
Prevalence of human papillomavirus in inverted nasal papillomas.
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DOI：
10.1001/archotol.1988.01860130027009
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
R. Weber;E. Shillitoe;K. Robbins;M. Luna;J. Batsakis;D. Donovan;K. Adler‐Storthz
中科院分区：
文献类型：
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作者：
R. Weber;E. Shillitoe;K. Robbins;M. Luna;J. Batsakis;D. Donovan;K. Adler‐Storthz
人乳头瘤病毒（HPV）与头颈部的良性和恶性肿瘤有关。为了确定这种肿瘤中HPV的流行率和类型，我们通过原位杂交检查了21例患者的固定组织。使用人乳头瘤病毒6 b型和11型探针，21例患者中有16例（76%）的病变中两种类型的杂交均呈阳性。与HPV-11探针杂交导致整个上皮细胞核染色最强烈，可能表明高拷贝数。在这种肿瘤中发现的病毒DNA序列的高发病率表明了潜在的病因作用。简要讨论了治疗意义。
Human papillomaviruses (HPVs) have been associated with both benign and malignant neoplasms of the head and neck. To determine the prevalence and types of HPVs in this neoplasm, we examined fixed tissue from 21 patients by in situ hybridization. Human papillomavirus types 6b and 11 probes were used, and hybridization was positive to both types in lesions from 16 (76%) of 21 patients. Hybridization to the HPV-11 probe resulted in the most intense nuclear staining throughout the epithelium, probably indicating a high copy number. The high incidence of viral DNA sequences found in this tumor suggests a potential etiologic role. Therapeutic implications are briefly discussed.