Childhood adversity and DNA methylation of genes involved in the hypothalamus-pituitary-adrenal axis and immune system: whole-genome and candidate-gene associations.
Childhood adversity and DNA methylation of genes involved in the hypothalamus-pituitary-adrenal axis and immune system: whole-genome and candidate-gene associations.
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DOI：
10.1017/s0954579412000806
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发表时间：
2012-11
影响因子：
3.3
通讯作者：
Grigorenko EL
中科院分区：
文献类型：
--
作者：
Bick J;Naumova O;Hunter S;Barbot B;Lee M;Luthar SS;Raefski A;Grigorenko EL
近年来，涉及人类和动物的转化研究发现了生物和生理途径，这些途径解释了早期不良环境与长期身心健康结果之间的关联。在这篇文章中，我们总结了人类和动物的文献表明，表观遗传学改变的关键生物系统，下丘脑-垂体-肾上腺轴和免疫系统，可能是这种差异的基础。我们回顾的证据表明，基因组的DNA甲基化谱的变化可能是下丘脑-垂体-肾上腺轴和免疫系统轨迹的改变。使用一些初步的数据，我们展示了如何探索全基因组和候选基因DNA甲基化谱可以告知假说，并指导未来的研究工作在这些领域。我们通过讨论许多重要的未来方向来结束我们的文章，合并来自发展心理学，分子遗传学，神经内分泌学和免疫学的观点，这对于进一步了解早期不利环境如何塑造发展轨迹至关重要，特别是在应激反应和身心健康领域。
In recent years, translational research involving humans and animals has uncovered biological and physiological pathways that explain associations between early adverse circumstances and long-term mental and physical health outcomes. In this article, we summarize the human and animal literature demonstrating that epigenetic alterations in key biological systems, the hypothalamus–pituitary–adrenal axis and immune system, may underlie such disparities. We review evidence suggesting that changes in DNA methylation profiles of the genome may be responsible for the alterations in hypothalamus–pituitary–adrenal axis and immune system trajectories. Using some preliminary data, we demonstrate how explorations of genome-wide and candidate-gene DNA methylation profiles may inform hypotheses and guide future research efforts in these areas. We conclude our article by discussing the many important future directions, merging perspectives from developmental psychology, molecular genetics, neuroendocrinology, and immunology, that are essential for furthering our understanding of how early adverse circumstances may shape developmental trajectories, particularly in the areas of stress reactivity and physical or mental health.