Complexity of the mouse gut T cell immune system: Identification of two distinct natural killer T cell intraepithelial lineages
Complexity of the mouse gut T cell immune system: Identification of two distinct natural killer T cell intraepithelial lineages
复制标题
DOI：
10.1002/eji.1830260942
复制
发表时间：
1996-09-01
影响因子：
5.4
通讯作者：
Vassalli, P
中科院分区：
文献类型：
--
作者：
GuyGrand, D;CuenodJabri, B;Vassalli, P
肠道胸腺依赖性(CD8α(+)β(+)或CD4(+))或非依赖性(CD8α(+)β(-))上皮内I淋巴细胞(IEL)在T细胞受体(TCR)-CD3信号转导后介导细胞毒作用，但只有TCRγβ(+)和αβ(+)非胸腺非依赖性IEL表现出自然杀伤(NK)和抗体依赖细胞介导的细胞毒作用类型。更有甚者。TCRαβ(+)和Gamma Delta(+)非依赖百里香的IEL表达NK受体。因此可称为NK-T IEL。NK-Tiel细胞毒作用是通过穿孔素介导的。快速或两者兼而有之。与其他NK细胞不同，这种细胞毒性不受通过识别主要组织相容性复合体I类分子而传递的信号的负面调节。因此，肠道IEL包括具有独特特异性和功能的T细胞亚群，在个体发育上有别于其他T细胞谱系，这可能增加参与防御上皮屏障的免疫系统的抗原谱多样性。
Gut thymo-dependent (CD8 alpha(+)beta(+) or CD4(+)) or -independent (CD8 alpha(+)beta(-)) intraepithelial I lymphocytes (IEL) mediate cytotoxicity following T cell receptor (TCR)-CD3 signaling, but only TCR gamma delta(+) and alpha beta(+) thyme-independent IEL show cytotoxicity of natural killer (NK) and antibody-dependent cell-mediated cytotoxicity types. Moreover. TCR alpha beta(+) and gamma delta(+) thyme-independent IEL express NK receptors. and may therefore be referred to as NK-T IEL. NK-TIEL cytotoxicity is mediated through perforin. Fast or both pathways. In contrast to that of other NK cells, this cytotoxicity is not negatively regulated by signals delivered through the recognition of major histocompatibility complex class I molecules. Thus, gut IEL include T cell subsets with unique specificities and functions, ontogenically distinct from other T cell lineages, which may increase the antigenic repertoire diversity of the immune system participating in the defense of the epithelial barrier.