A common genetic variant is associated with adult and childhood obesity
A common genetic variant is associated with adult and childhood obesity
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DOI：
10.1126/science.1124779
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发表时间：
2006-04-14
期刊：
影响因子：
56.9
通讯作者：
Christman, MF
中科院分区：
文献类型：
--
作者：
Herbert, A;Gerry, NP;Christman, MF
肥胖是一种可遗传的特征，也是许多常见疾病的风险因素，如2型糖尿病、心脏病和高血压。我们对弗雷明翰心脏研究参与者的DNA样本进行了密集的全基因组扫描，以确定INSIG2基因附近与肥胖相关的常见遗传变异。我们在四个不同的样本中重复了这一发现，这些样本包括西欧血统的个人、非裔美国人和儿童。肥胖易感基因存在于10%的个体中。我们的研究表明，常见的基因多态是肥胖的重要决定因素。
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.