Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS.
Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS.
复制标题
微生物行为调节剂 HHQ 和 PQS 类似物中 C-3 位置的结构功能分析。
DOI：
10.1039/c2ob26823j
复制
发表时间：
2012
影响因子：
3.2
通讯作者：
G. McGlacken
中科院分区：
文献类型：
--
作者：
F. Reen;Sarah L. Clarke;C. Legendre;Christina M. McSweeney;Kevin S. Eccles;S. Lawrence;F. O'Gara;G. McGlacken
2-庚基-3-羟基-4-喹诺酮（PQS）及其前体2-庚基-4-喹诺酮（HHQ）是重要的院内致病菌铜绿假单胞菌的关键信号分子。我们最近报道了这些分子的界际维度，影响了广谱微生物物种和人类致病性酵母菌白色念珠菌的关键毒力性状。首次对C-3位进行了有针对性的化学衍生化，以研究支撑这些化合物在铜绿假单胞菌中的生物活性的结构和分子特性，并使用枯草芽孢杆菌作为研究种间行为调节的合适模型系统。
2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour.
DOI：
10.1073/pnas.96.20.11229
发表时间：
1999-09-28
影响因子：
11.1
作者：
Pesci, EC;Milbank, JBJ;Iglewski, BH
通讯作者：
Iglewski, BH