Lipocalin-2 in the Inflammatory Activation of Brain Astrocytes
Lipocalin-2 in the Inflammatory Activation of Brain Astrocytes
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DOI：
10.1615/critrevimmunol.2015012127
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发表时间：
2015-01-01
影响因子：
1.3
通讯作者：
Suk, Kyoungho
中科院分区：
文献类型：
--
作者：
Lee, Shinrye;Jha, Mithilesh Kumar;Suk, Kyoungho
脂质运载蛋白-2（LCN 2）是一种分泌性蛋白，调节多种细胞过程，如细胞死亡/存活、细胞迁移/侵袭、细胞分化、铁递送、炎症、胰岛素抵抗和组织再生。最近，我们报道，LCN 2分泌的脑星形胶质细胞在炎症条件下，它促进细胞凋亡，形态学变化，并在体外和体内星形胶质细胞迁移。活化的星形胶质细胞释放LCN 2不仅诱导与反应性星形胶质细胞增多相关的形态学转化，而且促进其自身死亡。在炎症条件下，活化的星形胶质细胞也显示出类似于小胶质细胞和巨噬细胞的M1/M2表型的功能二分法。LCN 2被认为是一种趋化因子诱导剂和星形胶质细胞经典促炎激活的自分泌启动子。本文总结了目前关于星形胶质细胞衍生的LCN 2作为中枢神经系统促炎介质的作用的知识，并讨论了LCN 2在神经炎症性疾病中的作用。
Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery, inflammation, insulin resistance, and tissue regeneration. Recently, we reported that LCN2 is secreted by brain astrocytes under inflammatory conditions and that it promotes apoptosis, morphological changes, and migration in astrocytes both in vitro and in vivo. Activated astrocytes release LCN2 not only to induce the morphological transformation associated with reactive astrocytosis, but also to promote their own death. Under inflammatory conditions, activated astrocytes also show functional dichotomy similar to the M1/M2 phenotypes of microglia and macrophages. LCN2 is thought to be a chemokine inducer and an autocrine promoter of the classical proinflammatory activation of astrocytes. This article summarizes the current knowledge regarding the role of astrocyte-derived LCN2 as a proinflammatory mediator in the central nervous system and discusses LCN2's role in neuroinflammatory disorders.