Mechanosensory Feedback in Lamprey Swimming Models and Applications in the Field of Spinal Cord Regeneration
Mechanosensory Feedback in Lamprey Swimming Models and Applications in the Field of Spinal Cord Regeneration
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DOI：
10.1093/icb/icad079
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发表时间：
2023-06-24
影响因子：
2.6
通讯作者：
Hamlet，Christina L.
中科院分区：
文献类型：
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作者：
Katz，Hilary R.;Hamlet，Christina L.
中央模式发生器（CPG）在鳗形鱼游泳已作为一个模型，检查运动的神经基础。该系统对数学模型的发展特别有价值。随着我们对运动神经基础的生物学理解的扩展，这些模型也在扩展。最近，我们对机械感觉反馈在强健运动中所起的关键作用的理解有了重大进展。这项工作推动了数学建模领域将机械感觉反馈纳入CPG模型。在这篇文章中，我们回顾了这些模型的发展进展，并讨论了更新的复杂模型如何支持生物学研究。我们强调七鳃鳗脊髓再生作为一个领域，既可以告知这些模型，并从中受益。
The central pattern generator (CPG) in anguilliform swimming has served as a model for examining the neural basis of locomotion. This system has been particularly valuable for the development of mathematical models. As our biological understanding of the neural basis of locomotion has expanded, so too have these models. Recently, there have been significant advancements in our understanding of the critical role that mechanosensory feedback plays in robust locomotion. This work has led to a push in the field of mathematical modeling to incorporate mechanosensory feedback into CPG models. In this perspective piece, we review advances in the development of these models and discuss how newer complex models can support biological investigation. We highlight lamprey spinal cord regeneration as an area that can both inform these models and benefit from them.