Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology
Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology
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DOI：
10.1097/00041433-200210000-00004
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发表时间：
2002-10
影响因子：
4.4
通讯作者：
K. Tamama;F. Okajima
中科院分区：
文献类型：
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作者：
K. Tamama;F. Okajima
综述目的 1-磷酸鞘氨醇是一种新型脂质介质，对内皮细胞和血管平滑肌细胞发挥多种作用。在这篇综述中，我们讨论了有关血管生物学分子的最新发现。最近的发现已经证明，大多数 1-磷酸鞘氨醇诱导的作用是由其受体的 Edg 家族介导的。 1-磷酸鞘氨醇刺激内皮细胞的迁移和增殖，并对内皮细胞具有细胞保护作用。最近报道了磷酸肌醇 3-激酶和一氧化氮参与内皮细胞中鞘氨醇 1-磷酸下游信号传导，以及该分子诱导的内皮屏障完整性的增强。 1-磷酸鞘氨醇抑制血管平滑肌细胞的迁移，据报道这种抑制是通过抑制 Rac 介导的。 1-磷酸鞘氨醇浓缩在血浆中的脂蛋白部分，高密度脂蛋白通过其成分发挥内皮细胞保护作用。摘要 1-磷酸鞘氨醇可能在动脉粥样硬化的发展中发挥关键作用。
Purpose of review Sphingosine 1-phosphate is a novel lipid mediator which exerts various actions on endothelial cells and vascular smooth muscle cells. In this review, we discuss the latest findings about the molecule in vascular biology. Recent findings It has been demonstrated that most sphingosine 1-phosphate-induced actions are mediated by the Edg-family of its receptors. Sphingosine 1-phosphate stimulates the migration and proliferation of endothelial cells and is cytoprotective towards them. The involvement of phosphoinositide 3-kinase and nitric oxide in sphingosine 1-phosphate downstream signaling in endothelial cells was recently reported, as was the enhancement of endothelial barrier integrity induced by the molecule. Sphingosine 1-phosphate inhibits migration of vascular smooth muscle cells and this inhibition was reported to be mediated by inhibition of Rac. Sphingosine 1-phosphate is concentrated in the lipoprotein fraction in plasma, and high-density lipoprotein exerted endothelial cytoprotection through its component of this molecule. Summary Sphingosine 1-phosphate might play a critical role in the development of atherosclerosis.