DNA METHYLATION DECREASES IN AGING BUT NOT IN IMMORTAL CELLS
DNA METHYLATION DECREASES IN AGING BUT NOT IN IMMORTAL CELLS
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DOI：
10.1126/science.6844925
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
JONES P A
中科院分区：
文献类型：
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作者：
WILSON V L;JONES P A
当来自小鼠、仓鼠和人类的正常二倍体成纤维细胞在培养物中生长时，其DNA的5-甲基胞嘧啶含量显着降低。在小鼠细胞中观察到5-甲基胞嘧啶残基的最大损失率，其存活的分裂次数最少。永生小鼠细胞系具有更稳定的甲基化速率。
When normal diploid fibroblasts from mice, hamsters and humans were grown in culture, the 5-methylcytosine content of their DNA markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of divisions. Immortal mouse cell lines had more stable rates of methylation.