SEGREGATION OF MHC CLASS-II MOLECULES FROM MHC CLASS-I MOLECULES IN THE GOLGI-COMPLEX FOR TRANSPORT TO LYSOSOMAL COMPARTMENTS
SEGREGATION OF MHC CLASS-II MOLECULES FROM MHC CLASS-I MOLECULES IN THE GOLGI-COMPLEX FOR TRANSPORT TO LYSOSOMAL COMPARTMENTS
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DOI：
10.1038/349669a0
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发表时间：
1991-02-21
期刊：
影响因子：
64.8
通讯作者：
GEUZE, HJ
中科院分区：
文献类型：
--
作者：
PETERS, PJ;NEEFJES, JJ;GEUZE, HJ
MHC 分子的运输决定了呈递给 T 细胞的肽的来源。 MHC I 类和 II 类分子的细胞内分布分别反映了内源性和外源性抗原呈递的二分性。在人B类淋巴母细胞中，I类分子存在于构成生物合成途径的区室中，而II类分子在生物合成过程中进入与溶酶体相关的结构。
Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.