Myocardial expression of Fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy
Myocardial expression of Fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy
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DOI：
10.1016/j.jacc.2005.05.067
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发表时间：
2005-09-20
影响因子：
24
通讯作者：
McNamara, DM
中科院分区：
文献类型：
--
作者：
Sheppard, R;Bedi, M;McNamara, DM
目的 本研究旨在评估基因表达在预测新发心肌病心肌恢复中的作用。背景细胞凋亡可能限制心室恢复。我们检测了多中心心肌炎和急性心肌病干预 (IMAC) 研究患者中 Fas、Fas 配体 (FasL)、肿瘤坏死因子 (TNF)-α 和 TNF 受体 1 (TNFR1) 的心肌表达以及心肌恢复情况。 方法 采集 20 名新发（< 6 个月）特发性扩张型心肌病（左心室射血分数）患者的心内膜心肌活检样本[左心室射血分数]
OBJECTIVES This study aimed to evaluate the role of gene expression for predicting myocardial recovery in recent-onset cardiomyopathy.BACKGROUND Apoptosis may limit ventricular recovery. We examined the myocardial expression of Fas, Fas ligand (FasL), tumor necrosis factor (TNF)-alpha, and TNF receptor 1 (TNFR1), and myocardial recovery in patients from the multicenter Intervention in Myocarditis and Acute Cardiomyopathy (IMAC) study.METHODS Endomyocardial biopsy samples were obtained in 20 patients with recent-onset (< 6 months) idiopathic dilated cardiomyopathy (left ventricular ejection fraction [LVEF]